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slit guidance ligand 1

Summary

Gene Symbol

Slit1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

65047

PubChem

65047

Alliance of Genome Resources

RGD:69307

Annotation

Keyword

Alternative splicing
Developmental protein
Differentiation
Disulfide bond
EGF-like domain
Glycoprotein
Leucine-rich repeat
Neurogenesis
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6JH83
O88279	Multiple epidermal growth factor-like domains protein 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 18** of 18 in total

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GO Term	Evidence Code	PMID
axonogenesis	ISO
cell differentiation	IEA
negative regulation of synapse assembly	ISS

GO Hierarchy

biological process

cellular process [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

cellular developmental process [inference]

cell differentiation

cell motility [inference]

cell migration [inference]

forebrain cell migration [inference]

telencephalon cell migration

tangential migration from the subventricular zone to the olfactory bulb

cellular localization [inference]

intracellular transport [inference]

nuclear migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

axonogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

axonogenesis

anatomical structure development [inference]

system development [inference]

nervous system development

cellular developmental process [inference]

cell differentiation

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis

chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

nuclear migration

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear migration

establishment of organelle localization [inference]

nuclear migration

organelle localization [inference]

nucleus localization [inference]

nuclear migration

establishment of organelle localization [inference]

nuclear migration

cellular localization [inference]

intracellular transport [inference]

nuclear migration

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of developmental growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly

negative regulation of synapse organization [inference]

negative regulation of synapse assembly

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of synapse assembly

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of synapse assembly

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

regulation of chemotaxis [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of chemotaxis [inference]

negative regulation of axon extension involved in axon guidance

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of developmental growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of developmental growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of synapse assembly

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

negative regulation of synapse assembly

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cellular process [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly

negative regulation of synapse organization [inference]

negative regulation of synapse assembly

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of extent of cell growth [inference]

regulation of axon extension [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axon extension involved in axon guidance [inference]

negative regulation of axon extension involved in axon guidance

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of axonogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

negative regulation of synapse assembly

negative regulation of synapse organization [inference]

negative regulation of synapse assembly

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly

negative regulation of synapse organization [inference]

negative regulation of synapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

negative regulation of synapse assembly

negative regulation of cell junction assembly [inference]

negative regulation of synapse assembly

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of synapse assembly

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of axonogenesis [inference]

negative regulation of axon extension [inference]

negative regulation of axon extension involved in axon guidance

negative regulation of synapse assembly

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular region	IEA
extracellular space	IBA IDA IEA ISO	15632296

GO Hierarchy

cellular component

cellular anatomical entity [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	15528323
heparin binding	IBA
heparan sulfate proteoglycan binding	IDA	10364234
signaling receptor binding	IEA
Roundabout binding	IBA IEA ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

Roundabout binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

proteoglycan binding [inference]

heparan sulfate proteoglycan binding

sulfur compound binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

slit homolog 1 protein

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying **all 7** entries
Gene Ontology
Roundabout binding
calcium ion binding
cell differentiation
heparin binding
negative chemotaxis
nervous system development
signaling receptor binding

Displaying entries **1 - 10** of 14 in total

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2

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InterPro
Concanavalin A-like lectin/glucanase domain superfamily
Cysteine-rich flanking region, C-terminal
Cystine knot, C-terminal
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-like, conserved site
EGF-type aspartate/asparagine hydroxylation site
Follistatin-like, N-terminal
Laminin G domain

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:15632296

Ortholog

Displaying entries **1 - 10** of **102** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6585		HGNC:11085	HUMAN02360
Mus musculus	20562	10090_1:0052a9	MGI:1315203	MOUSE25796
Drosophila melanogaster	36746		FB:FBgn0264089
Canis lupus familiaris	486818			CANLF11348
Bos taurus	510761			BOVIN21274
Danio rerio	556123		ZFIN:ZDB-GENE-030722-3	DANRE05063
Danio rerio	561685		ZFIN:ZDB-GENE-030722-4
Macaca mulatta	705901			MACMU46670
Xenopus tropicalis	100036682		Xenbase:XB-GENE-1007728
Taeniopygia guttata	100226609			TAEGU27108

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Last updated: December 9, 2024