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solute carrier family 2 member 5

Summary

Gene Symbol

SLC2A5

Organism

Homo sapiens (human)

External Links

NCBI Gene

6518

HGNC

11010

KEGG Gene ID

hsa:6518

PubChem

6518

Alliance of Genome Resources

HGNC:11010

Annotation

Keyword

Acetylation
Alternative splicing
Cell membrane
Glycoprotein
Reference proteome
Sugar transport
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B4DG19
P22732	Fructose transporter Glucose transporter type 5, small intestine
A0A140VJK5	Fructose transporter Glucose transporter type 5, small intestine

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
glucose transmembrane transport	TAS	1695905
fructose transmembrane transport	IBA IDA	28083649 29548810
cellular response to fructose stimulus	ISS
carbohydrate metabolic process	TAS	1634504
fructose import across plasma membrane	IDA	8333543

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

carbohydrate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to fructose stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to fructose stimulus

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

fructose transmembrane transport

fructose import across plasma membrane

hexose import across plasma membrane [inference]

fructose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

fructose import across plasma membrane

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

fructose import across plasma membrane

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal hexose absorption

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to fructose

cellular response to fructose stimulus

cellular response to hexose stimulus [inference]

cellular response to fructose stimulus

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to fructose stimulus

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to fructose stimulus

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to fructose stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to fructose stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to fructose stimulus

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to fructose

cellular response to fructose stimulus

cellular response to hexose stimulus [inference]

cellular response to fructose stimulus

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to fructose stimulus

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to fructose stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to fructose stimulus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to fructose stimulus

cellular response to oxygen-containing compound [inference]

cellular response to carbohydrate stimulus [inference]

cellular response to monosaccharide stimulus [inference]

cellular response to hexose stimulus [inference]

cellular response to fructose stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

intestinal absorption [inference]

intestinal hexose absorption

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

fructose transmembrane transport

fructose import across plasma membrane

hexose import across plasma membrane [inference]

fructose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

fructose import across plasma membrane

import across plasma membrane [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

fructose import across plasma membrane

organic substance transport [inference]

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

fructose transmembrane transport

fructose import across plasma membrane

hexose import across plasma membrane [inference]

fructose import across plasma membrane

glucose transmembrane transport

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

fructose import across plasma membrane

intestinal hexose absorption

import into cell [inference]

carbohydrate import across plasma membrane [inference]

hexose import across plasma membrane [inference]

fructose import across plasma membrane

biological regulation [inference]

regulation of biological quality [inference]

regulation of blood pressure [inference]

regulation of systemic arterial blood pressure [inference]

regulation of systemic arterial blood pressure mediated by a chemical signal

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
plasma membrane	IBA IDA TAS	28083649 8333543
membrane
sarcolemma	ISS
apical plasma membrane	ISS
extracellular exosome	HDA	19056867 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

sarcolemma

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

specific granule membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

specific granule membrane

plasma membrane region [inference]

apical plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
glucose transmembrane transporter activity	IEA
fructose binding	ISS
protein binding	IPI	32296183
fructose transmembrane transporter activity	IBA IDA TAS	28083649 29548810 8333543

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

carbohydrate transmembrane transporter activity [inference]

sugar transmembrane transporter activity [inference]

monosaccharide transmembrane transporter activity [inference]

hexose transmembrane transporter activity [inference]

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

fructose binding

small molecule binding [inference]

monosaccharide binding [inference]

fructose binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000142583

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K08143

Name

MFS transporter, SP family, solute carrier family 2 (facilitated glucose/fructose transporter), member 5

References

Disease

Disease Ontology

Displaying entries **1 - 10** of 52 in total

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DO ID	Disease Name	Source
DOID:2998	testicular cancer	DisGeNET
DOID:0014667	disease of metabolism	DisGeNET
DOID:0050156	idiopathic pulmonary fibrosis	DisGeNET
DOID:0050387	nonpapillary renal cell carcinoma	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET
DOID:0080146	childhood B-cell acute lymphoblastic leukemia	DisGeNET
DOID:10283	prostate cancer	DisGeNET DisGeNET
DOID:10286	prostate carcinoma	DisGeNET DisGeNET
DOID:10486	intestinal atresia	DisGeNET
DOID:10607	tropical sprue	DisGeNET

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178921	WB:WBGene00016431
Caenorhabditis elegans	187167	WB:WBGene00010684
Caenorhabditis elegans	189599	WB:WBGene00012536
Caenorhabditis elegans	192084	WB:WBGene00006865
Drosophila melanogaster	35520	FB:FBgn0033047
Drosophila melanogaster	44268	FB:FBgn0028561
Drosophila melanogaster	44269	FB:FBgn0028562
Latimeria chalumnae	102351891		LATCH20252
Danio rerio	100006415	ZFIN:ZDB-GENE-060222-2
Ictalurus punctatus	108276125		ICTPU07900