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solute carrier family 6 member 2

Summary

Gene Symbol

SLC6A2

Organism

Homo sapiens (human)

External Links

NCBI Gene

6530

PubChem

6530

Alliance of Genome Resources

HGNC:11048

Annotation

Keyword

Alternative splicing
Cell membrane
Disease variant
Disulfide bond
Glycoprotein
Metal-binding
Neurotransmitter transport
Reference proteome
Sodium
Symport
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P23975	Norepinephrine transporter Solute carrier family 6 member 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
neurotransmitter transport	ISS
amino acid transport	IBA
chemical synaptic transmission	TAS	2008212
response to xenobiotic stimulus	IEA
monoamine transport	IDA	16024787

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

multicellular organismal process [inference]

multicellular organismal response to stress [inference]

response to pain

homeostatic process [inference]

cellular homeostasis [inference]

neuron cellular homeostasis

response to stimulus [inference]

response to stress [inference]

multicellular organismal response to stress [inference]

response to pain

response to chemical [inference]

response to xenobiotic stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

neurotransmitter transport

neurotransmitter uptake [inference]

neurotransmitter reuptake [inference]

catecholamine uptake involved in synaptic transmission [inference]

dopamine uptake involved in synaptic transmission

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

organic substance transport [inference]

organic cation transport [inference]

norepinephrine transport

norepinephrine uptake

organic anion transport [inference]

carboxylic acid transport [inference]

amino acid transport

monoamine transport

catecholamine transport [inference]

dopamine transport [inference]

dopamine uptake [inference]

dopamine uptake involved in synaptic transmission

norepinephrine transport

norepinephrine uptake

catecholamine uptake [inference]

norepinephrine uptake

catecholamine uptake involved in synaptic transmission [inference]

dopamine uptake involved in synaptic transmission

dopamine uptake [inference]

dopamine uptake involved in synaptic transmission

organic acid transport [inference]

carboxylic acid transport [inference]

amino acid transport

organic hydroxy compound transport [inference]

catecholamine transport [inference]

dopamine transport [inference]

dopamine uptake [inference]

dopamine uptake involved in synaptic transmission

norepinephrine transport

norepinephrine uptake

catecholamine uptake [inference]

norepinephrine uptake

catecholamine uptake involved in synaptic transmission [inference]

dopamine uptake involved in synaptic transmission

dopamine uptake [inference]

dopamine uptake involved in synaptic transmission

nitrogen compound transport [inference]

amino acid transport

monoamine transport

catecholamine transport [inference]

dopamine transport [inference]

dopamine uptake [inference]

dopamine uptake involved in synaptic transmission

norepinephrine transport

norepinephrine uptake

catecholamine uptake [inference]

norepinephrine uptake

catecholamine uptake involved in synaptic transmission [inference]

dopamine uptake involved in synaptic transmission

dopamine uptake [inference]

dopamine uptake involved in synaptic transmission

import into cell [inference]

neurotransmitter uptake [inference]

neurotransmitter reuptake [inference]

catecholamine uptake involved in synaptic transmission [inference]

dopamine uptake involved in synaptic transmission

establishment of localization in cell [inference]

neurotransmitter reuptake [inference]

catecholamine uptake involved in synaptic transmission [inference]

dopamine uptake involved in synaptic transmission

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	11343649
plasma membrane	IBA
cell surface	IEA
membrane	TAS	2008212

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell surface

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

cell body membrane [inference]

neuronal cell body membrane

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
actin binding	IPI	18331289
neurotransmitter transmembrane transporter activity	ISS
neurotransmitter:sodium symporter activity	IEA
dopamine:sodium symporter activity	IDA	11093780 8125921
dopamine:sodium symporter activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

neurotransmitter transmembrane transporter activity

neurotransmitter:sodium symporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

solute:sodium symporter activity [inference]

neurotransmitter:sodium symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

neurotransmitter:sodium symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

solute:sodium symporter activity [inference]

neurotransmitter:sodium symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

organic cation transmembrane transporter activity [inference]

norepinephrine:sodium symporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

neurotransmitter:sodium symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

active transmembrane transporter activity [inference]

monoamine transmembrane transporter activity

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

solute:sodium symporter activity [inference]

neurotransmitter:sodium symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

solute:sodium symporter activity [inference]

neurotransmitter:sodium symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

organic hydroxy compound transmembrane transporter activity [inference]

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

neurotransmitter:sodium symporter activity

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

tubulin binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transporter

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
symporter activity

Displaying **all 2** entries
InterPro
Sodium
Sodium

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050741	alcohol dependence	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:11569	neurocirculatory asthenia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6530	Xenbase:XB-GENE-486549
Drosophila melanogaster	6531	FB:FBgn0034136
Drosophila melanogaster	13162	FB:FBgn0034136
Mus musculus	20538	Xenbase:XB-GENE-486549	MOUSE59237
Drosophila melanogaster	24898	FB:FBgn0034136
Xenopus tropicalis	36849	Xenbase:XB-GENE-486549
Rattus norvegicus	83511		RATNO15326
Xenopus tropicalis	176304	Xenbase:XB-GENE-486549
Bos taurus	282363		BOVIN10455
Pan troglodytes	454096		PANTR12381

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Annotation

OrthoDB (Group)

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Acknowledgements