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solute carrier family 19 member 1

Summary

Gene Symbol

SLC19A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6573

KEGG Gene ID

PubChem

6573

Alliance of Genome Resources

HGNC:10937

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Antiport
Cell membrane
Disease variant
Folate-binding
Glycoprotein
Hereditary hemolytic anemia
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P41440	Cyclic dinucleotide:anion antiporter SLC19A1 Folate:anion antiporter SLC19A1 Intestinal folate carrier 1 Placental folate transporter Reduced folate carrier protein Reduced folate transporter 1 Solute carrier family 19 member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 25 in total

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GO Term	Evidence Code	PMID
folic acid transport	ISS
folic acid transport	TAS
folic acid transport	IMP
folic acid transport	IEA
folic acid metabolic process	TAS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

folic acid metabolic process

small molecule metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

dicarboxylic acid metabolic process [inference]

folic acid metabolic process

transmembrane transport

xenobiotic transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

vitamin transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

import across plasma membrane [inference]

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

multi-multicellular organism process [inference]

female pregnancy

response to stimulus [inference]

response to chemical [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

monoatomic anion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

vascular transport [inference]

transport across blood-brain barrier

organophosphate ester transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

adenine nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

cyclic nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport

folate transmembrane transport

folate import across plasma membrane

methotrexate transport

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

xenobiotic transport [inference]

xenobiotic transmembrane transport

vitamin transport

folic acid transport

folate transmembrane transport

folate import across plasma membrane

vitamin transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

transmembrane transport

xenobiotic transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

vitamin transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

import across plasma membrane [inference]

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

adenine nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

cyclic nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

methotrexate transport

modified amino acid transport [inference]

folic acid transport

folate transmembrane transport

folate import across plasma membrane

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

import into cell [inference]

import across plasma membrane [inference]

carbohydrate derivative transport [inference]

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of intracellular signal transduction [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of intracellular signal transduction [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cGAS/STING signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of intracellular signal transduction [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of intracellular signal transduction [inference]

positive regulation of cGAS/STING signaling pathway

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
plasma membrane	EXP
plasma membrane	TAS
plasma membrane	IDA
plasma membrane	IBA
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
folic acid binding	IBA
folic acid binding	IEA
obsolete organic anion transmembrane transporter activity
folic acid transmembrane transporter activity	ISS

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic anion transmembrane transporter activity [inference]

folate:monoatomic anion antiporter activity

organophosphate ester transmembrane transporter activity [inference]

nucleotide transmembrane transporter activity [inference]

purine nucleotide transmembrane transporter activity [inference]

adenine nucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

guanine nucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

purine ribonucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

nucleobase-containing compound transmembrane transporter activity [inference]

nucleotide transmembrane transporter activity [inference]

purine nucleotide transmembrane transporter activity [inference]

adenine nucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

guanine nucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

purine ribonucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity

folate:monoatomic anion antiporter activity

xenobiotic transmembrane transporter activity

methotrexate transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

folic acid transmembrane transporter activity

folate:monoatomic anion antiporter activity

methotrexate transmembrane transporter activity

modified amino acid transmembrane transporter activity [inference]

folic acid transmembrane transporter activity

folate:monoatomic anion antiporter activity

vitamin transmembrane transporter activity

folic acid transmembrane transporter activity

folate:monoatomic anion antiporter activity

carbohydrate derivative transmembrane transporter activity [inference]

purine ribonucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

binding [inference]

protein binding

small molecule binding [inference]

vitamin binding [inference]

folic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

folic acid binding

2',3'-cyclic GMP-AMP binding

organic acid binding [inference]

carboxylic acid binding [inference]

folic acid binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

guanyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

cyclic nucleotide binding [inference]

cyclic GMP-AMP binding [inference]

2',3'-cyclic GMP-AMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

guanyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

folic acid binding

modified amino acid binding [inference]

folic acid binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

guanyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

guanyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

cyclic nucleotide binding [inference]

cyclic GMP-AMP binding [inference]

2',3'-cyclic GMP-AMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

guanyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:9296	cleft lip	Alliance of Genome Resources
DOID:0060770	dextro-looped transposition of the great arteries	Alliance of Genome Resources
DOID:7693	abdominal aortic aneurysm	Alliance of Genome Resources
DOID:2531	hematologic cancer	Alliance of Genome Resources
DOID:12365	malaria	Alliance of Genome Resources
DOID:612	primary immunodeficiency disease	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Rattus norvegicus	29723	RGD:3695
Caenorhabditis elegans	179544	WB:WBGene00007388

GlyTouCan

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