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solute carrier family 19 member 1

Summary

Gene Symbol

Slc19a1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

29723

PubChem

29723

Alliance of Genome Resources

RGD:3695

Annotation

Keyword

Acetylation
Antiport
Cell membrane
Folate-binding
Glycoprotein
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q62866	Methotrexate carrier 1 Plasma membrane folate antiporter SLC19A1 Reduced folate carrier 1 Solute carrier family 19 member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
xenobiotic transmembrane transport	IMP	21737571
female pregnancy	IEP	18776693
response to xenobiotic stimulus	IEP	20451541
response to toxic substance	IEP	20451541
organic anion transport	IMP	18762716

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

xenobiotic transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

vitamin transmembrane transport

folate transmembrane transport

folate import across plasma membrane

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

import across plasma membrane [inference]

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

reproductive process [inference]

multi-organism reproductive process [inference]

female pregnancy

multicellular organismal process [inference]

multi-multicellular organism process [inference]

female pregnancy

response to stimulus [inference]

response to chemical [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic anion transport [inference]

monoatomic anion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

xenobiotic transport [inference]

xenobiotic transmembrane transport

vitamin transport [inference]

folic acid transport

folate transmembrane transport

folate import across plasma membrane

vitamin transmembrane transport

folate transmembrane transport

folate import across plasma membrane

transmembrane transport [inference]

xenobiotic transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

vitamin transmembrane transport

folate transmembrane transport

folate import across plasma membrane

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

import across plasma membrane [inference]

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

organic substance transport [inference]

organic anion transport

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport

folate transmembrane transport

folate import across plasma membrane

methotrexate transport

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

cyclic-GMP-AMP transmembrane import across plasma membrane

organophosphate ester transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

adenine nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

cyclic nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

folic acid transport

folate transmembrane transport

folate import across plasma membrane

methotrexate transport

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

folate transmembrane transport

folate import across plasma membrane

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

adenine nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

cyclic nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

modified amino acid transport [inference]

folic acid transport

folate transmembrane transport

folate import across plasma membrane

methotrexate transport

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

carbohydrate derivative transport [inference]

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleotide transport [inference]

purine nucleotide transport [inference]

guanine nucleotide transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

purine ribonucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

adenine nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

cyclic nucleotide transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

nucleotide transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

amide transport [inference]

folic acid transport

folate transmembrane transport

folate import across plasma membrane

methotrexate transport

modified amino acid transport [inference]

folic acid transport

folate transmembrane transport

folate import across plasma membrane

methotrexate transport

purine-containing compound transmembrane transport [inference]

guanine nucleotide transmembrane transport [inference]

cyclic-GMP-AMP transmembrane import across plasma membrane

import into cell [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of cytoplasmic pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of cGAS/STING signaling pathway

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	IBA
plasma membrane	IEA
basolateral plasma membrane	ISO
basolateral plasma membrane	IDA	15846510 19243012 21556118

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
folic acid binding	IDA	11600421
folic acid binding	IBA
organic anion transmembrane transporter activity	IMP	18762716
folic acid transmembrane transporter activity	ISO
folate:monoatomic anion antiporter activity	ISO

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

methotrexate transmembrane transporter activity

folic acid transmembrane transporter activity

folate:monoatomic anion antiporter activity

organic anion transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

methotrexate transmembrane transporter activity

folic acid transmembrane transporter activity

folate:monoatomic anion antiporter activity

cyclic-GMP-AMP transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic anion transmembrane transporter activity [inference]

folate:monoatomic anion antiporter activity

active monoatomic ion transmembrane transporter activity [inference]

folate:monoatomic anion antiporter activity

organophosphate ester transmembrane transporter activity [inference]

nucleotide transmembrane transporter activity [inference]

purine nucleotide transmembrane transporter activity [inference]

adenine nucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

guanine nucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

purine ribonucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

nucleobase-containing compound transmembrane transporter activity [inference]

nucleotide transmembrane transporter activity [inference]

purine nucleotide transmembrane transporter activity [inference]

adenine nucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

guanine nucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

purine ribonucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity

folate:monoatomic anion antiporter activity

active monoatomic ion transmembrane transporter activity [inference]

folate:monoatomic anion antiporter activity

amide transmembrane transporter activity [inference]

folic acid transmembrane transporter activity

folate:monoatomic anion antiporter activity

methotrexate transmembrane transporter activity

xenobiotic transmembrane transporter activity

methotrexate transmembrane transporter activity

modified amino acid transmembrane transporter activity [inference]

folic acid transmembrane transporter activity

folate:monoatomic anion antiporter activity

methotrexate transmembrane transporter activity

vitamin transmembrane transporter activity

folic acid transmembrane transporter activity

folate:monoatomic anion antiporter activity

carbohydrate derivative transmembrane transporter activity [inference]

purine ribonucleotide transmembrane transporter activity [inference]

cyclic-GMP-AMP transmembrane transporter activity

salt transmembrane transporter activity [inference]

methotrexate transmembrane transporter activity

binding [inference]

amide binding [inference]

folic acid binding

small molecule binding [inference]

vitamin binding [inference]

folic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

folic acid binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

guanyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

cyclic nucleotide binding [inference]

cyclic GMP-AMP binding [inference]

2',3'-cyclic GMP-AMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

guanyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

folic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

folic acid binding

2',3'-cyclic GMP-AMP binding

modified amino acid binding [inference]

folic acid binding

organic cyclic compound binding [inference]

folic acid binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

guanyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

cyclic nucleotide binding [inference]

cyclic GMP-AMP binding [inference]

2',3'-cyclic GMP-AMP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

guanyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

guanyl ribonucleotide binding [inference]

2',3'-cyclic GMP-AMP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Thiamine transporter

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
vitamin transmembrane transport
vitamin transport

Displaying **all 2** entries
InterPro
MFS transporter superfamily
Reduced folate carrier

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
basolateral plasma membrane	PMID:15846510 PMID:19243012
brush border membrane	PMID:23287122

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6573	Xenbase:XB-GENE-979559	HUMAN58967
Drosophila melanogaster	10560	FB:FBgn0037846
Mus musculus	20509		MOUSE02395
Xenopus tropicalis	29723	Xenbase:XB-GENE-979559
Drosophila melanogaster	80704	FB:FBgn0037846
Drosophila melanogaster	80721	FB:FBgn0037846
Drosophila melanogaster	116914	FB:FBgn0037846
Danio rerio	178745	ZFIN:ZDB-GENE-110401-1
Xenopus tropicalis	179544	Xenbase:XB-GENE-979559
Pan troglodytes	474051		PANTR25851

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

OrthoDB (Group)

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Acknowledgements