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solute carrier family 22 member 5

Summary

Gene Symbol

SLC22A5

Organism

Homo sapiens (human)

External Links

NCBI Gene

6584

PubChem

6584

Alliance of Genome Resources

HGNC:10969

Annotation

Keyword

ATP-binding
Alternative splicing
Cell membrane
Disease variant
Endoplasmic reticulum
Glycoprotein
Phosphoprotein
Reference proteome
Sodium transport
Symport
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O76082	High-affinity sodium-dependent carnitine cotransporter Solute carrier family 22 member 5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 19 in total

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GO Term	Evidence Code	PMID
sodium-dependent organic cation transport	IDA	15238359 9685390
transport across blood-brain barrier	ISS
transport across blood-brain barrier	NAS	26590417 30280653
(R)-carnitine transport	IDA	17509700 20722056 33334877
(R)-carnitine transmembrane transport	ISS

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

carnitine transmembrane transport

(R)-carnitine transmembrane transport

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to symbiont [inference]

response to symbiotic bacterium

response to bacterium [inference]

response to symbiotic bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to symbiont [inference]

response to symbiotic bacterium

response to bacterium [inference]

response to symbiotic bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to symbiont [inference]

response to symbiotic bacterium

response to bacterium [inference]

response to symbiotic bacterium

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

vascular transport [inference]

transport across blood-brain barrier

xenobiotic transport [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

transmembrane transport [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

carnitine transmembrane transport

(R)-carnitine transmembrane transport

organic substance transport [inference]

organic cation transport [inference]

carnitine transport

(R)-carnitine transport

(R)-carnitine transmembrane transport

carnitine transmembrane transport

(R)-carnitine transmembrane transport

sodium-dependent organic cation transport

quaternary ammonium group transport

amino-acid betaine transport [inference]

carnitine transport

(R)-carnitine transport

(R)-carnitine transmembrane transport

carnitine transmembrane transport

(R)-carnitine transmembrane transport

modified amino acid transport [inference]

amino-acid betaine transport [inference]

carnitine transport

(R)-carnitine transport

(R)-carnitine transmembrane transport

carnitine transmembrane transport

(R)-carnitine transmembrane transport

nitrogen compound transport [inference]

quaternary ammonium group transport

amino-acid betaine transport [inference]

carnitine transport

(R)-carnitine transport

(R)-carnitine transmembrane transport

carnitine transmembrane transport

(R)-carnitine transmembrane transport

modified amino acid transport [inference]

amino-acid betaine transport [inference]

carnitine transport

(R)-carnitine transport

(R)-carnitine transmembrane transport

carnitine transmembrane transport

(R)-carnitine transmembrane transport

export from cell [inference]

xenobiotic export from cell [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

export across plasma membrane [inference]

xenobiotic detoxification by transmembrane export across the plasma membrane

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal epithelial structure maintenance

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of digestive system process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal epithelial structure maintenance

regulation of intestinal epithelial structure maintenance [inference]

positive regulation of intestinal epithelial structure maintenance

positive regulation of multicellular organismal process [inference]

positive regulation of digestive system process [inference]

positive regulation of intestinal epithelial structure maintenance

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISS
endoplasmic reticulum	IDA	17509700
endoplasmic reticulum	IEA
cytosol	ISS
plasma membrane	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	15523054 28514442 32296183 33961781
ATP binding	IEA
amino-acid betaine transmembrane transporter activity	IDA	33124720
carnitine transmembrane transporter activity	EXP	9685390
carnitine transmembrane transporter activity	TAS

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic cation transmembrane transporter activity [inference]

quaternary ammonium group transmembrane transporter activity

amino-acid betaine transmembrane transporter activity

carnitine transmembrane transporter activity

(R)-carnitine transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity

xenobiotic transmembrane transporter activity

modified amino acid transmembrane transporter activity [inference]

amino-acid betaine transmembrane transporter activity

carnitine transmembrane transporter activity

(R)-carnitine transmembrane transporter activity

binding [inference]

protein binding

protein domain specific binding [inference]

PDZ domain binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Solute carrier family 22 member 22

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
MFS transporter superfamily
Major facilitator superfamily domain
Major facilitator, sugar transporter-like

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0050700	cardiomyopathy	Alliance of Genome Resources
DOID:14365	systemic primary carnitine deficiency disease	Alliance of Genome Resources
DOID:655	inherited metabolic disorder	Alliance of Genome Resources
DOID:8778	Crohn's disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **125** in total

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Species	Gene ID	Alliance of Genome Resources
Saccharomyces cerevisiae S288C	6580	SGD:S000000695
Saccharomyces cerevisiae S288C	6581	SGD:S000000695
Saccharomyces cerevisiae S288C	6582	SGD:S000000695
Xenopus tropicalis	6583	Xenbase:XB-GENE-484416
Xenopus tropicalis	6584	Xenbase:XB-GENE-5858686
Saccharomyces cerevisiae S288C	9356	SGD:S000000695
Saccharomyces cerevisiae S288C	9376	SGD:S000000695
Caenorhabditis elegans	9389	WB:WBGene00003842
Saccharomyces cerevisiae S288C	9390	SGD:S000000695
Saccharomyces cerevisiae S288C	10864	SGD:S000000695