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sorbitol dehydrogenase

Summary

Gene Symbol

SORD

Organism

Homo sapiens (human)

External Links

NCBI Gene

6652

HGNC

11184

KEGG Gene ID

hsa:6652

PubChem

6652

Alliance of Genome Resources

HGNC:11184

JoGo

SORD

TogoVar

SORD

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Direct protein sequencing
Disease variant
Flagellum
Membrane
Metal-binding
Mitochondrion
NAD
Neuropathy
Oxidoreductase
Phosphoprotein
Proteomics identification
Reference proteome
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q00796	(R,R)-butanediol dehydrogenase L-iditol 2-dehydrogenase Polyol dehydrogenase Ribitol dehydrogenase Xylitol dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
glucose metabolic process	TAS
D-sorbitol catabolic process	IDA
D-sorbitol catabolic process	IMP
D-sorbitol catabolic process	IBA
obsolete D-glucuronate catabolic process to D-xylulose 5-phosphate	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule-based movement [inference]

cilium movement [inference]

cilium movement involved in cell motility [inference]

flagellated sperm motility

metabolic process [inference]

catabolic process [inference]

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

D-sorbitol catabolic process

pentitol catabolic process [inference]

xylitol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

D-sorbitol catabolic process

pentitol catabolic process [inference]

xylitol catabolic process

biosynthetic process [inference]

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose biosynthetic process

glucose metabolic process

hexose biosynthetic process [inference]

fructose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

hexitol metabolic process [inference]

D-sorbitol metabolic process [inference]

D-sorbitol catabolic process

hexitol catabolic process [inference]

D-sorbitol catabolic process

carbohydrate biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

carbohydrate catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

D-sorbitol catabolic process

pentitol catabolic process [inference]

xylitol catabolic process

pentitol metabolic process [inference]

pentitol catabolic process [inference]

xylitol catabolic process

xylitol metabolic process

xylitol catabolic process

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fructose metabolic process [inference]

fructose biosynthetic process

glucose metabolic process

hexose biosynthetic process [inference]

fructose biosynthetic process

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

alcohol metabolic process [inference]

polyol metabolic process [inference]

hexitol metabolic process [inference]

D-sorbitol metabolic process [inference]

D-sorbitol catabolic process

hexitol catabolic process [inference]

D-sorbitol catabolic process

pentitol metabolic process [inference]

pentitol catabolic process [inference]

xylitol catabolic process

xylitol metabolic process

xylitol catabolic process

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

D-sorbitol catabolic process

pentitol catabolic process [inference]

xylitol catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

D-sorbitol catabolic process

pentitol catabolic process [inference]

xylitol catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

alditol catabolic process [inference]

hexitol catabolic process [inference]

D-sorbitol catabolic process

pentitol catabolic process [inference]

xylitol catabolic process

small molecule biosynthetic process [inference]

monosaccharide biosynthetic process [inference]

hexose biosynthetic process [inference]

fructose biosynthetic process

cell motility [inference]

cilium or flagellum-dependent cell motility [inference]

cilium-dependent cell motility [inference]

flagellated sperm motility

sperm motility [inference]

flagellated sperm motility

reproductive process [inference]

sperm motility [inference]

flagellated sperm motility

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
cytosol	IEA
membrane	IDA
motile cilium	ISS
motile cilium	IEA
mitochondrial membrane	ISS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

mitochondrial membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium [inference]

motile cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium [inference]

motile cilium

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
(R,R)-butanediol dehydrogenase activity	EXP
(R,R)-butanediol dehydrogenase activity	IEA
L-iditol 2-dehydrogenase (NAD+) activity	ISS
L-iditol 2-dehydrogenase (NAD+) activity	EXP
L-iditol 2-dehydrogenase (NAD+) activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

(R,R)-butanediol dehydrogenase activity

alcohol dehydrogenase [NAD(P)+] activity [inference]

alcohol dehydrogenase (NAD+) activity

L-iditol 2-dehydrogenase (NAD+) activity

hexitol dehydrogenase activity [inference]

D-xylulose reductase activity

binding [inference]

protein binding [inference]

identical protein binding

carbohydrate binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000140263

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00008

Name

L-iditol 2-dehydrogenase [EC:1.1.1.14]

References

Rhea

RHEA:20433

xylitol + NAD⁺

H⁺ + D-xylulose + NADH

Enzyme

1.1.1.9

PMID

17216457

RHEA:20053

ribitol + NAD⁺

H⁺ + D-ribulose + NADH

Enzyme

1.1.1.56

PMID

RHEA:10160

L-iditol + NAD⁺

keto-L-sorbose + H⁺ + NADH

Enzyme

1.1.1.14

PMID

RHEA:24340

(R,R)-butane-2,3-diol + NAD⁺

H⁺ + (R)-acetoin + NADH

Enzyme

1.1.1.4

PMID

RHEA:33031

H⁺ + keto-D-fructose + NADH

D-sorbitol + NAD⁺

Enzyme

1.1.1.14

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0081427	autosomal recessive distal hereditary motor neuronopathy 8	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 11 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0001761	Pes cavus
HP:0002355	Difficulty walking
HP:0002495	Impaired vibratory sensation
HP:0002650	Scoliosis
HP:0003431	Decreased motor nerve conduction velocity
HP:0007078	Decreased amplitude of sensory action potentials
HP:0007328	Impaired pain sensation
HP:0008959	Distal upper limb muscle weakness
HP:0008994	Proximal muscle weakness in lower limbs

Displaying 1 entry
Disease ID	Disease Name
OMIM:618912	neuronopathy, distal hereditary motor, autosomal recessive 8

PubChem Disease

MedGen Diseases

Neuronopathy, distal hereditary motor, autosomal recessive 8

OMIM Phenotypes

NEURONOPATHY, DISTAL HEREDITARY MOTOR, AUTOSOMAL RECESSIVE 8; HMNR8

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Saccharomyces cerevisiae S288C	851351	SGD:S000002405
Saccharomyces cerevisiae S288C	850759	SGD:S000004060
Saccharomyces cerevisiae S288C	853624	SGD:S000003920
Mus musculus	20322	MGI:98266
Rattus norvegicus	24788	RGD:3734

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements