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histocompatibility 2, Q region locus 8

Summary

Gene Symbol

H2-Q8

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

68395

PubChem

68395

Alliance of Genome Resources

MGI:95937

Annotation

Keyword

Glycoprotein
MHC I
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P79567

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA
positive regulation of T cell mediated cytotoxicity	IBA
immune response	IBA
antigen processing and presentation of peptide antigen via MHC class I	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response

antigen processing and presentation [inference]

antigen processing and presentation via MHC class Ib [inference]

antigen processing and presentation of peptide antigen via MHC class Ib [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous antigen [inference]

antigen processing and presentation of endogenous peptide antigen [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class I [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of peptide antigen via MHC class Ib [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of peptide antigen via MHC class I

antigen processing and presentation of endogenous peptide antigen via MHC class I [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

antigen processing and presentation of endogenous peptide antigen [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class Ib

antigen processing and presentation of endogenous peptide antigen via MHC class I [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of leukocyte mediated immunity [inference]

regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of lymphocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of cellular process [inference]

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of T cell mediated immunity [inference]

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T cell mediated immunity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of cellular process [inference]

regulation of cell killing [inference]

regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

regulation of T cell mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

positive regulation of cellular process [inference]

positive regulation of cell killing [inference]

positive regulation of leukocyte mediated cytotoxicity [inference]

positive regulation of T cell mediated cytotoxicity

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
external side of plasma membrane	IBA
MHC class I protein complex	IEA
cell surface	ISO
extracellular space	IBA
lumenal side of endoplasmic reticulum membrane	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

MHC protein complex [inference]

MHC class I protein complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

bounding membrane of organelle [inference]

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

side of membrane [inference]

external side of plasma membrane

lumenal side of membrane [inference]

lumenal side of endoplasmic reticulum membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
beta-2-microglobulin binding	ISO
signaling receptor binding	IBA
protein-containing complex binding	ISO
peptide antigen binding	IBA
peptide binding	ISO

GO Hierarchy

molecular function

binding [inference]

antigen binding [inference]

peptide antigen binding

protein binding [inference]

amide binding [inference]

peptide binding

peptide antigen binding

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0081267	graft-versus-host disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 35 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3136	HGNC:4965
Rattus norvegicus	24973	RGD:1595924
Rattus norvegicus	24974	RGD:1595923
Rattus norvegicus	309600		RATNO22559
Rattus norvegicus	309603	RGD:1595869	RATNO22559
Rattus norvegicus	309607	RGD:1595868	RATNO22494
Rattus norvegicus	368153	RGD:1595786	RATNO22494
Rattus norvegicus	414779	RGD:1598235	RATNO22546
Rattus norvegicus	414789	RGD:1359630
Rattus norvegicus	414791		RATNO22494