GlyCosmos Portal

Submissions

LMBR1 domain containing 1

Summary

Gene Symbol

Lmbrd1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

68421

PubChem

68421

Alliance of Genome Resources

MGI:1915671

Annotation

Keyword

Alternative splicing
Cell membrane
Cobalamin
Cytoplasmic vesicle
Endocytosis
Endoplasmic reticulum
Gastrulation
Glycoprotein
Lysosome
Phosphoprotein
Reference proteome
Transmembrane helix
Transport

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8K0B2	LMBR1 domain-containing protein 1 Protein N90b

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
gastrulation	IMP	27061115
insulin receptor internalization	IMP	24078630
negative regulation of glucose import
negative regulation of insulin receptor signaling pathway
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to vacuole [inference]

protein localization to lysosome

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

gastrulation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to vacuole [inference]

protein localization to lysosome

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

receptor internalization [inference]

insulin receptor internalization

clathrin-dependent endocytosis

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to vacuole [inference]

protein localization to lysosome

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of glucose transmembrane transport [inference]

negative regulation of glucose transmembrane transport [inference]

negative regulation of glucose import

regulation of glucose import [inference]

negative regulation of glucose import

negative regulation of transmembrane transport [inference]

negative regulation of glucose transmembrane transport [inference]

negative regulation of glucose import

negative regulation of transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of glucose transmembrane transport [inference]

negative regulation of glucose import

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of transmembrane transport [inference]

negative regulation of glucose transmembrane transport [inference]

negative regulation of glucose import

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of glucose transmembrane transport [inference]

negative regulation of glucose import

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of transmembrane transport [inference]

regulation of glucose transmembrane transport [inference]

negative regulation of glucose transmembrane transport [inference]

negative regulation of glucose import

regulation of glucose import [inference]

negative regulation of glucose import

negative regulation of transmembrane transport [inference]

negative regulation of glucose transmembrane transport [inference]

negative regulation of glucose import

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

negative regulation of transmembrane transport [inference]

negative regulation of glucose transmembrane transport [inference]

negative regulation of glucose import

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
lysosome	IDA	24078630
lysosomal membrane	ISS
lysosomal membrane	ISO
lysosomal membrane	IBA
endoplasmic reticulum membrane	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

clathrin-coated endocytic vesicle

endocytic vesicle [inference]

clathrin-coated endocytic vesicle

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
insulin receptor binding	IDA	24078630
protein binding	IPI	24078630
cobalamin binding	IEA
clathrin heavy chain binding	IDA	24078630
AP-2 adaptor complex binding	IMP	24078630

GO Hierarchy

molecular function

transporter activity [inference]

protein transporter activity

binding [inference]

protein binding

signaling receptor binding [inference]

insulin receptor binding

clathrin binding [inference]

clathrin heavy chain binding

small molecule binding [inference]

vitamin binding [inference]

cobalamin binding

heterocyclic compound binding [inference]

cobalamin binding

protein-containing complex binding [inference]

AP-2 adaptor complex binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

cobalamin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

lysosomal cobalamin transporter

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
cobalamin binding
protein localization to lysosome

Displaying 1 entry
InterPro
LMBR1-like membrane protein

Ortholog

Displaying entries **71 - 77** of 77 in total

« First

‹ Prev

…

4

5

6

7

8
Species	Gene ID	Orthologous MAtrix
Corvus moneduloides	116442124	CORMO19042
Chelonoidis abingdonii	116819011	CHEAB22892
Rhinolophus ferrumequinum	117020484	RHIFE11159
Scophthalmus maximus	118283935	SCOMX08229
Balaenoptera musculus	118905216	BALMU27568
Panthera leo	122220065	PANLE15875
Cavia porcellus	134470768	CAVPO03022