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transporter 1, ATP binding cassette subfamily B member

Summary

Gene Symbol

TAP1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6890

PubChem

6890

Alliance of Genome Resources

HGNC:43

Annotation

Keyword

3D-structure
ATP-binding
Adaptive immunity
Alternative initiation
Endoplasmic reticulum
Host-virus interaction
Magnesium
Metal-binding
Peptide transport
Reference proteome
Translocase
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
B7Z7P4
Q03518	ATP-binding cassette sub-family B member 2 Peptide supply factor 1 Peptide transporter PSF1 Peptide transporter TAP1 Peptide transporter involved in antigen processing 1 Really interesting new gene 4 protein
A0A0S2Z5A6
X5CKB3

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
adaptive immune response	IEA
defense response	IEA
protein transport	IEA
peptide transport	IMP	11133832 17418234
antigen processing and presentation of endogenous peptide antigen via MHC class I	IDA	11133832

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

antigen processing and presentation [inference]

antigen processing and presentation of endogenous antigen [inference]

antigen processing and presentation of endogenous peptide antigen [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I

antigen processing and presentation of peptide antigen [inference]

antigen processing and presentation of peptide antigen via MHC class I [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I

antigen processing and presentation of endogenous peptide antigen [inference]

antigen processing and presentation of endogenous peptide antigen via MHC class I

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

cytosol to endoplasmic reticulum transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

transmembrane transport

cytosol to endoplasmic reticulum transport

response to stimulus [inference]

response to stress [inference]

defense response

immune response [inference]

adaptive immune response

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

cytosol to endoplasmic reticulum transport

transmembrane transport

cytosol to endoplasmic reticulum transport

organic substance transport [inference]

nitrogen compound transport [inference]

protein transport

amide transport [inference]

peptide transport

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

cytosol to endoplasmic reticulum transport

cellular localization [inference]

intracellular transport [inference]

cytosol to endoplasmic reticulum transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	IDA
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IDA	11133832 15577206 22638925 7673167
membrane	IDA	8955196
membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

endoplasmic reticulum protein-containing complex [inference]

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

bounding membrane of organelle [inference]

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

endoplasmic reticulum-Golgi intermediate compartment membrane

centriolar satellite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

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GO Term	Evidence Code	PMID
protein binding	IPI	12213826 15793001 16828748 17055437 18802093 19165146 19201886 19297616 22810586 26789246 28514442 30833792 32296183 33961781
ATP binding	IDA	11133832 7673167
ATP binding	IMP	15793001
ABC-type peptide antigen transporter activity	IDA	11133832 25377891
ABC-type peptide antigen transporter activity	IMP	17418234 25656091

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

transporter activity [inference]

transmembrane transporter activity [inference]

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity [inference]

ABC-type peptide transporter activity [inference]

ABC-type peptide antigen transporter activity

amide transmembrane transporter activity [inference]

peptide transmembrane transporter activity

ABC-type peptide transporter activity [inference]

ABC-type peptide antigen transporter activity

binding [inference]

antigen binding [inference]

peptide antigen binding

protein binding

signaling receptor binding [inference]

MHC protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

TAP binding [inference]

protein dimerization activity [inference]

protein homodimerization activity

amide binding [inference]

peptide binding [inference]

peptide antigen binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

ADP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ABC-type transporter activity [inference]

ABC-type peptide transporter activity [inference]

ABC-type peptide antigen transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

atp-binding cassette sub-family c

Functional Category

K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
ABC-type transporter activity
ATP binding
nucleotide binding

Displaying **all 6** entries
InterPro
AAA+ ATPase domain
ABC transporter type 1, transmembrane domain superfamily
ABC transporter type 1, transmembrane domain
ABC transporter-like, ATP-binding domain
ABC transporter-like, conserved site
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0060009	MHC class I deficiency	Alliance of Genome Resources
DOID:1067	open-angle glaucoma	Alliance of Genome Resources
DOID:1205	allergic disease	Alliance of Genome Resources
DOID:1580	diffuse scleroderma	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:2957	pulmonary tuberculosis	Alliance of Genome Resources
DOID:4362	cervical cancer	Alliance of Genome Resources
DOID:4483	rhinitis	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources
DOID:6196	reactive arthritis	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6890	Xenbase:XB-GENE-486762
Mus musculus	21354		MOUSE20135
Caenorhabditis elegans	23457	WB:WBGene00001814
Rattus norvegicus	24811		RATNO22094
Pan troglodytes	471978		PANTR37860
Canis lupus familiaris	474866		CANLF02611
Bos taurus	524959		BOVIN18257
Macaca mulatta	717726		MACMU34722
Sus scrofa	733649		PIGXX31288
Monodelphis domestica	100026750		MONDO12669

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Annotation

OrthoDB (Group)

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Acknowledgements