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MIRAGE
transforming growth factor beta receptor 2
Summary
- Gene Symbol
-
- TGFBR2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Aortic aneurysm
- Apoptosis
- Cell membrane
- Craniosynostosis
- Differentiation
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Growth regulation
- Hereditary nonpolyposis colorectal cancer
- Magnesium
- Manganese
- Metal-binding
- Phosphoprotein
- Receptor
- Reference proteome
- Secreted
- Serine/threonine-protein kinase
- Signal
- Transmembrane helix
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| blood vessel development | ||
| branching involved in blood vessel morphogenesis | ||
| vasculogenesis | ||
| in utero embryonic development | ||
| epithelial to mesenchymal transition |
GO Hierarchy
biological process
cellular process [inference]
developmental process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of tolerance induction [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of metabolic process
regulation of signaling [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of cellular process [inference]
positive regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cell population proliferation
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
positive regulation of cell activation [inference]
regulation of multicellular organismal process
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
positive regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| extracellular space | ||
| cytosol | ||
| plasma membrane | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein serine/threonine kinase activity | ||
| transmembrane receptor protein serine/threonine kinase activity | ||
| transforming growth factor beta receptor activity | ||
| transforming growth factor beta receptor activity | ||
| transforming growth factor beta receptor activity |
GO Hierarchy
- molecular adaptor activity
molecular function
catalytic activity [inference]
binding [inference]
molecular transducer activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- TGF-beta receptor type-2
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ATP binding |
| SMAD binding |
| activin binding |
| activin receptor activity |
| anatomical structure morphogenesis |
| cell differentiation |
| kinase activity |
| metal ion binding |
| nucleotide binding |
| phosphorylation |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0070234 | Loeys-Dietz syndrome 2 | |
| DOID:0070273 | hereditary nonpolyposis colorectal cancer type 6 | |
| DOID:0112182 | mismatch repair cancer syndrome | |
| DOID:14323 | Marfan syndrome | |
| DOID:1793 | pancreatic cancer | |
| DOID:219 | colon cancer | |
| DOID:3748 | esophagus squamous cell carcinoma | |
| DOID:3883 | Lynch syndrome |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 92 | WB:WBGene00000900 | ||
| 93 | WB:WBGene00000900 | ||
| 7048 | Xenbase:XB-GENE-485606 | ||
| 11480 | WB:WBGene00000900 | ||
| 11481 | WB:WBGene00000900 | ||
| 21813 | Xenbase:XB-GENE-485606 | MOUSE63853 | |
| 25366 | WB:WBGene00000900 | ||
| 29263 | WB:WBGene00000900 | ||
| 30739 | DANRE10303 | ||
| 81810 | Xenbase:XB-GENE-485606 | RATNO41472 |
