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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Lynch syndrome
Summary
- Synonym
-
- COCA 1
- HNPCC - hereditary nonpolyposis colon cancer
- Hereditary Defective Mismatch Repair syndrome
- Hereditary non-polyposis colon cancer
- Hereditary non-polyposis colon cancer syndrome
- Hereditary non-polyposis colorectal cancer
- Hereditary non-polyposis colorectal cancer syndrome
- Hereditary nonpolyposis colon cancer
- Hereditary nonpolyposis colon cancer syndrome
- Hereditary nonpolyposis colorectal cancer syndrome
- hereditary nonpolyposis colorectal cancer
- hereditary nonpolyposis colorectal neoplasm
- Definition
- A syndrome that is characterized by an increased risk for colon cancer and cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, urinary tract, brain, and skin and has_material_basis_in mutation of mismatch repair genes that increases the risk of many types of cancers.
- Super Class
- autosomal dominant disease syndrome
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 92 | ACVR2A | activin A receptor type 2A | |
| 768 | CA9 | carbonic anhydrase 9 | |
| 771 | CA12 | carbonic anhydrase 12 | |
| 1874 | E2F4 | E2F transcription factor 4 | |
| 2956 | MSH6 | mutS homolog 6 | |
| 3845 | KRAS | KRAS proto-oncogene, GTPase | |
| 4082 | MARCKS | myristoylated alanine rich protein kinase C substrate | |
| 4089 | SMAD4 | SMAD family member 4 | |
| 4292 | MLH1 | mutL homolog 1 | |
| 4361 | MRE11 | MRE11 homolog, double strand break repair nuclease |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 11480 | Acvr2a | activin receptor IIA | |
| 16653 | Kras | Kirsten rat sarcoma viral oncogene homolog | |
| 17126 | Smad2 | SMAD family member 2 | |
| 17128 | Smad4 | SMAD family member 4 | |
| 17350 | Mlh1 | mutL homolog 1 | |
| 17688 | Msh6 | mutS homolog 6 | |
| 21413 | Tcf4 | transcription factor 4 | |
| 21812 | Tgfbr1 | transforming growth factor, beta receptor I | |
| 21813 | Tgfbr2 | transforming growth factor, beta receptor II | |
| 68195 | Rnaset2b | ribonuclease T2B |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 174044 | sma-6 | Serine/threonine-protein kinase receptor sma-6 | |
| 175781 | daf-4 | Cell surface receptor daf-4;Serine/threonine-protein kinase receptor;receptor protein serine/threonine kinase | |
| 176829 | daf-1 | Cell surface receptor daf-1 | |
| 190096 | rnst-2 | Ribonuclease T2 protein rnst-2 |
