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transmembrane and tetratricopeptide repeat containing 4

Summary

Gene Symbol

Tmtc4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

70551

KEGG Gene ID

mmu:70551

PubChem

70551

Alliance of Genome Resources

MGI:1921050

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Glycoprotein
Reference proteome
Repeat
TPR repeat
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8BG19	Transmembrane O-mannosyltransferase targeting cadherins 4 Transmembrane and tetratricopeptide repeat-containing 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
sensory perception of sound	IMP	30188326
sensory perception of sound	IGI	30188326
endoplasmic reticulum unfolded protein response	IMP	30188326
endoplasmic reticulum unfolded protein response	IBA
positive regulation of endoplasmic reticulum calcium ion concentration	IMP	30188326

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

mannosylation [inference]

protein mannosylation [inference]

protein O-linked mannosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked mannosylation

protein mannosylation [inference]

protein O-linked mannosylation

cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process [inference]

outer hair cell apoptotic process

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

positive regulation of endoplasmic reticulum calcium ion concentration

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

positive regulation of endoplasmic reticulum calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

positive regulation of endoplasmic reticulum calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

positive regulation of endoplasmic reticulum calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

positive regulation of endoplasmic reticulum calcium ion concentration

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis [inference]

endoplasmic reticulum calcium ion homeostasis [inference]

positive regulation of endoplasmic reticulum calcium ion concentration

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

endoplasmic reticulum unfolded protein response

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

endoplasmic reticulum unfolded protein response

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	ISO	30188326
endoplasmic reticulum	IBA
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mannosyltransferase activity	IBA
dolichyl-phosphate-mannose-protein mannosyltransferase activity	ISS
dolichyl-phosphate-mannose-protein mannosyltransferase activity	ISO
ATPase binding	ISO	30188326

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

mannosyltransferase activity

dolichyl-phosphate-mannose-protein mannosyltransferase activity

catalytic activity, acting on a protein [inference]

dolichyl-phosphate-mannose-protein mannosyltransferase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

ATPase binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tpr repeat-containing protein

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
mannosyltransferase activity
protein O-linked mannosylation

Displaying **all 3** entries
InterPro
Protein O-mannosyl-transferase TMTC, DUF1736
Tetratricopeptide repeat
Tetratricopeptide-like helical domain superfamily

KEGG BRITE Database

Orthology

K23424

Name

protein O-mannosyl-transferase [EC:2.4.1.-]

References

28973932

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	41867	Xenbase:XB-GENE-5771787
Xenopus tropicalis	70551	Xenbase:XB-GENE-5771787
Homo sapiens	84899	Xenbase:XB-GENE-5771787	HUMAN17531
Xenopus tropicalis	185454	Xenbase:XB-GENE-5771787
Rattus norvegicus	290501	Xenbase:XB-GENE-5771787	RATNO10457
Pan troglodytes	452642		PANTR08029
Bos taurus	539972		BOVIN04081
Danio rerio	560605	Xenbase:XB-GENE-5771787	DANRE44143
Macaca mulatta	706341		MACMU17053
Monodelphis domestica	100025862		MONDO32254