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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
toll like receptor 4
Summary
- Gene Symbol
-
- TLR4
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Age-related macular degeneration
- Alternative splicing
- Cell membrane
- Cell projection
- Direct protein sequencing
- Disulfide bond
- Endosome
- Glycoprotein
- Inflammatory response
- Innate immunity
- Leucine-rich repeat
- NAD
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| O00206 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| positive regulation of B cell proliferation |
GO Hierarchy
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of reactive oxygen species biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of reactive oxygen species biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of reactive oxygen species biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of cellular response to macrophage colony-stimulating factor stimulus
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of MHC class II biosynthetic process
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of cellular response to macrophage colony-stimulating factor stimulus
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-10 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of cytokine production involved in inflammatory response
biological process
immune system process [inference]
metabolic process [inference]
cellular process [inference]
multicellular organismal process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
positive regulation of immune response [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
immune response-regulating signaling pathway [inference]
regulation of innate immune response [inference]
positive regulation of innate immune response [inference]
regulation of pattern recognition receptor signaling pathway [inference]
positive regulation of immune response [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of intracellular signal transduction [inference]
positive regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of immune response [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of signaling [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of response to stimulus [inference]
positive regulation of response to biotic stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of defense response [inference]
positive regulation of response to external stimulus [inference]
positive regulation of immune response [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
regulation of response to stimulus [inference]
regulation of response to biotic stimulus [inference]
positive regulation of response to biotic stimulus [inference]
regulation of innate immune response [inference]
positive regulation of innate immune response [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of intracellular signal transduction [inference]
regulation of response to external stimulus [inference]
positive regulation of response to external stimulus [inference]
regulation of innate immune response [inference]
positive regulation of innate immune response [inference]
regulation of pattern recognition receptor signaling pathway [inference]
positive regulation of response to stimulus [inference]
positive regulation of response to biotic stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of defense response [inference]
positive regulation of response to external stimulus [inference]
positive regulation of immune response [inference]
regulation of immune response [inference]
immune response-regulating signaling pathway [inference]
regulation of innate immune response [inference]
positive regulation of innate immune response [inference]
regulation of pattern recognition receptor signaling pathway [inference]
positive regulation of immune response [inference]
regulation of response to cytokine stimulus [inference]
regulation of response to stress [inference]
regulation of defense response [inference]
positive regulation of defense response [inference]
regulation of innate immune response [inference]
positive regulation of innate immune response [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
signal transduction [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of intracellular signal transduction [inference]
positive regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of macromolecule biosynthetic process [inference]
negative regulation of cellular biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
regulation of phosphorus metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
positive regulation of cell communication [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production [inference]
negative regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production [inference]
regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production [inference]
negative regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| receptor complex | ||
| cytoplasm | ||
| external side of plasma membrane | ||
| lipopolysaccharide receptor complex | ||
| cell surface |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| signaling receptor activity | ||
| protein binding | ||
| lipopolysaccharide immune receptor activity | ||
| protein heterodimerization activity | ||
| identical protein binding |
GO Hierarchy
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:854 | collagen disease | |
| DOID:8677 | perinatal necrotizing enterocolitis | |
| DOID:869 | cholesteatoma | |
| DOID:8893 | psoriasis | |
| DOID:8947 | diabetic retinopathy | |
| DOID:9111 | cutaneous leishmaniasis | |
| DOID:9351 | diabetes mellitus | |
| DOID:9352 | type 2 diabetes mellitus | |
| DOID:9675 | pulmonary emphysema | |
| DOID:9743 | diabetic neuropathy |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 34761 | FB:FBgn0026760 | ||
| 43222 | FB:FBgn0262473 | ||
| 403131 | ZFIN:ZDB-GENE-040219-8 | DANRE05736 | |
| 403132 | ZFIN:ZDB-GENE-040219-9 | DANRE05762 | |
| 795671 | ZFIN:ZDB-GENE-090507-2 | DANRE05767 | |
| 108263518 | ICTPU27038 | ||
| 101954201 | CHRPI14792 | ||
| 113443881 | PSETE16448 | ||
| 116234179 | PHACC10916 | ||
| 100540712 | MELGA05176 |
