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MIRAGE
tumor necrosis factor
Summary
- Gene Symbol
-
- TNF
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Cell membrane
- Cytokine
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Myristate
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Secreted
- Signal-anchor
- Transmembrane helix
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| negative regulation of transcription by RNA polymerase II | ||
| response to hypoxia | ||
| microglial cell activation | ||
| microglial cell activation | ||
| positive regulation of cytokine production |
GO Hierarchy
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- regulation of membrane lipid metabolic process
- regulation of reactive oxygen species metabolic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of synaptic transmission
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of synaptic transmission
- positive regulation of action potential
- positive regulation of synaptic transmission
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of hair follicle development
- positive regulation of synaptic transmission
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- regulation of membrane lipid metabolic process
- regulation of reactive oxygen species metabolic process
- positive regulation of synaptic transmission
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of DNA biosynthetic process
- positive regulation of nitric oxide biosynthetic process
- positive regulation of vitamin D biosynthetic process
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of type II interferon production
- positive regulation of interleukin-18 production
- positive regulation of interleukin-6 production
- positive regulation of interleukin-8 production
- positive regulation of interleukin-33 production
- positive regulation of cytokine production involved in inflammatory response
- positive regulation of hair follicle development
biological process
immune system process [inference]
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
positive regulation of immune system process [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
regulation of metabolic process
regulation of biosynthetic process [inference]
negative regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of RNA biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of protein metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of nitrogen compound metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of RNA biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of phosphorus metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of amide metabolic process [inference]
negative regulation of nitrogen compound metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of RNA biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of protein metabolic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of lipid metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of intracellular signal transduction [inference]
positive regulation of signaling [inference]
positive regulation of signal transduction [inference]
regulation of localization [inference]
regulation of transport [inference]
regulation of cellular localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of macromolecule metabolic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of protein metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of nitrogen compound metabolic process [inference]
positive regulation of signaling [inference]
positive regulation of signal transduction [inference]
positive regulation of cellular process [inference]
positive regulation of cell population proliferation [inference]
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of protein localization [inference]
positive regulation of response to stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of defense response [inference]
positive regulation of response to external stimulus [inference]
positive regulation of immune response [inference]
positive regulation of developmental process [inference]
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of cellular process [inference]
negative regulation of transport [inference]
negative regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of response to biotic stimulus [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of intracellular signal transduction [inference]
regulation of response to external stimulus [inference]
positive regulation of response to external stimulus [inference]
regulation of inflammatory response [inference]
positive regulation of response to stimulus [inference]
positive regulation of signal transduction [inference]
positive regulation of defense response [inference]
positive regulation of response to external stimulus [inference]
positive regulation of immune response [inference]
regulation of immune response [inference]
regulation of response to stress [inference]
regulation of defense response [inference]
regulation of developmental process [inference]
regulation of anatomical structure morphogenesis [inference]
regulation of cell differentiation [inference]
positive regulation of developmental process [inference]
regulation of multicellular organismal development [inference]
regulation of cellular process [inference]
signal transduction [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
positive regulation of signal transduction [inference]
regulation of intracellular signal transduction [inference]
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
regulation of cell adhesion [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production
regulation of DNA-templated transcription [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of RNA biosynthetic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
regulation of phosphorus metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
regulation of phosphate metabolic process [inference]
regulation of cell population proliferation [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
positive regulation of cell population proliferation [inference]
positive regulation of cell communication [inference]
positive regulation of signal transduction [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of phosphorus metabolic process [inference]
positive regulation of cellular biosynthetic process [inference]
positive regulation of macromolecule biosynthetic process [inference]
positive regulation of gene expression
positive regulation of cytokine production
positive regulation of protein localization [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cellular localization [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
positive regulation of cytokine production
positive regulation of multicellular organismal process [inference]
positive regulation of cytokine production
negative regulation of multicellular organismal process [inference]
regulation of multicellular organismal development [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| plasma membrane | ||
| external side of plasma membrane | ||
| cell surface | ||
| membrane | ||
| protein-containing complex |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| transcription cis-regulatory region binding | ||
| protease binding | ||
| cytokine activity | ||
| cytokine activity | ||
| cytokine activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- tumor necrosis factor
- Functional Category
-
- L: Replication, recombination and repair
- O: Posttranslational modification, protein turnover, chaperones
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:7148 | rheumatoid arthritis | |
| DOID:841 | extrinsic allergic alveolitis | |
| DOID:8505 | dermatitis herpetiformis | |
| DOID:8725 | vascular dementia | |
| DOID:874 | bacterial pneumonia | |
| DOID:8893 | psoriasis | |
| DOID:8947 | diabetic retinopathy | |
| DOID:9008 | psoriatic arthritis | |
| DOID:9074 | systemic lupus erythematosus | |
| DOID:9146 | visceral leishmaniasis |
