Submissions
GlyTouCan
Glycan Structure Repository
GlyComb
Glycoconjugate Repository
GlycoPOST
Glycomics MS raw data Repository
UniCarb-DR
Glycomics MS Repository for glycan annotations from GlycoWorkbench
LM-GlycoRepo
Repository for lectin-assisted multimodality data
Resources Genes Glycoproteins Lectins Glycolipids Glycans Pathways Diseases Organisms
All Resources
Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Other Information
Release Statistics Download
Tools
SugarDrawer GlycanBuilder Glycan Converters GlycoMaple GlycomeAtlas LM-GlycomeAtlas GALAXY MCAW GlycoSim GRable
Search Tools
Cross Search Glycan Search Publication Search Programmatic Access
Standards Ontologies Notations
Guidelines
MIRAGE
complement C1s

Summary
Gene Symbol
  • C1S
Organism
Homo sapiens (human)
NCBI Gene
716
PubChem
716
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Calcium
  • Complement pathway
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • EGF-like domain
  • Ehlers-Danlos syndrome
  • Glycoprotein
  • Hydroxylation
  • Innate immunity
  • Metal-binding
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Serine protease
  • Signal
  • Sushi
Proteins
Displaying all 2 entries
UniProt Protein Name
F8WCZ6
P09871
  • C1 esterase
  • Complement component 1 subcomponent s
Annotation information from UniProt.
Gene Ontology (GO)
Displaying all 4 entries
GO Term Evidence Code PMID
proteolysis
complement activation
complement activation, classical pathway
innate immune response
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
mannan-binding lectin serine
Functional Category
  • G: Carbohydrate transport and metabolism
  • O: Posttranslational modification, protein turnover, chaperones
  • T: Signal transduction mechanisms
Displaying all 9 entries
Gene Ontology
calcium ion binding
complement activation, classical pathway
complement activation
hydrolase activity
immune system process
metal ion binding
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity
Displaying entries 1 - 10 of 13 in total
InterPro
CUB domain
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Peptidase S1A, complement C1r/C1S/mannan-binding
Serine proteases, trypsin domain
Serine proteases, trypsin family, serine active site
Disease
Disease Ontology
Displaying 1 entry
DO ID Disease Name Source
DOID:0080987 Ehlers-Danlos syndrome periodontal type 2
Ortholog
Displaying entries 1 - 10 of 66 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
716 Xenbase:XB-GENE-995410
50908 Xenbase:XB-GENE-995410 MOUSE47990
192262 Xenbase:XB-GENE-995410 RATNO30568
317677 Xenbase:XB-GENE-995410 MOUSE48010
397274 PIGXX26277
451808 PANTR05021
486714 CANLF11120
714589 MACMU03332
767827 BOVIN30419
100016766 MONDO34593
About Release Notes Help Feedback
International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

Logo License Policies Site Map

Contact: support@glycosmos.org

This work is licensed under Creative Commons Attribution 4.0 International

GlyCosmos Portal v4.4.0

Last updated: December 8, 2025