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tryptophan hydroxylase 1

Summary

Gene Symbol

TPH1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7166

PubChem

7166

Alliance of Genome Resources

HGNC:12008

Annotation

Keyword

3D-structure
Alternative splicing
Iron
Metal-binding
Monooxygenase
Phosphoprotein
Reference proteome
Serotonin biosynthesis
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P17752	Tryptophan 5-monooxygenase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
negative regulation of ossification	IEA
response to immobilization stress	IEA
mammary gland alveolus development	IEA
serotonin biosynthetic process	IEA ISS
platelet degranulation	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

ammonium ion metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

primary amino compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

primary amino compound biosynthetic process [inference]

serotonin biosynthetic process

organonitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

primary amino compound biosynthetic process [inference]

serotonin biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

aromatic compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

organonitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

primary amino compound biosynthetic process [inference]

serotonin biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process

cellular aromatic compound metabolic process [inference]

aromatic amino acid metabolic process

phenol-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

aromatic compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

aromatic compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process

organic cyclic compound metabolic process [inference]

aromatic amino acid metabolic process

phenol-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

organic cyclic compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

primary amino compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

primary amino compound biosynthetic process [inference]

serotonin biosynthetic process

organonitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

primary amino compound biosynthetic process [inference]

serotonin biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

organonitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

primary amino compound biosynthetic process [inference]

serotonin biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular process [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process

cellular aromatic compound metabolic process [inference]

aromatic amino acid metabolic process

phenol-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

aromatic compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

aromatic compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

multicellular organismal process [inference]

tissue remodeling [inference]

bone remodeling

developmental process [inference]

anatomical structure development [inference]

mammary gland alveolus development

rhythmic process [inference]

circadian rhythm

response to stimulus [inference]

response to stress [inference]

response to immobilization stress

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

establishment of localization in cell [inference]

platelet degranulation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of ossification

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of cellular process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

negative regulation of ossification

negative regulation of multicellular organismal process [inference]

negative regulation of ossification

regulation of hemostasis

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of hemostasis

Displaying **all 2** entries
GO Term	Evidence Code	PMID
neuron projection	IBA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	28514442 32296183 32814053 33961781
iron ion binding	IEA
tryptophan 5-monooxygenase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [inference]

tryptophan 5-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [inference]

tryptophan 5-monooxygenase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

tryptophan 5-hydroxylase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
aromatic amino acid metabolic process
iron ion binding
metal ion binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
oxidoreductase activity

Displaying **all 7** entries
InterPro
ACT domain
ACT-like domain
Aromatic amino acid hydroxylase superfamily
Aromatic amino acid hydroxylase, C-terminal
Aromatic amino acid hydroxylase, iron/copper binding site
Aromatic amino acid hydroxylase
Aromatic amino acid monoxygenase, C-terminal domain superfamily

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0060249	scoliosis	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10930	borderline personality disorder	Alliance of Genome Resources
DOID:1094	attention deficit hyperactivity disorder	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:1596	depressive disorder	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources
DOID:9478	postpartum depression	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	21990		MGI:98796	MOUSE55780
Rattus norvegicus	24848		RGD:3895	RATNO16219
Drosophila melanogaster	38121		FB:FBgn0035187
Caenorhabditis elegans	174227		WB:WBGene00006600
Danio rerio	352943		ZFIN:ZDB-GENE-030317-1	DANRE51567
Xenopus laevis	387560		Xenbase:XB-GENE-996927
Danio rerio	415103		ZFIN:ZDB-GENE-030805-6
Pan troglodytes	466453	9598_0:002ff1		PANTR02421
Canis lupus familiaris	611956			CANLF08581
Macaca mulatta	695363			MACMU09098

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International Collaboration

Acknowledgements