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MIRAGE

tryptophan hydroxylase 1

Summary

Gene Symbol

TPH1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7166

PubChem

7166

Alliance of Genome Resources

HGNC:12008

JoGo

TPH1

TogoVar

TPH1

Annotation

Keyword

3D-structure
Alternative splicing
Iron
Metal-binding
Monooxygenase
Phosphoprotein
Proteomics identification
Reference proteome
Serotonin biosynthesis
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P17752	Tryptophan 5-monooxygenase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **11 - 11** of 11 in total

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GO Term	Evidence Code	PMID
regulation of hemostasis	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

ammonium ion metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

primary amino compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

primary amino compound biosynthetic process [inference]

serotonin biosynthetic process

organonitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

primary amino compound biosynthetic process [inference]

serotonin biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

aromatic compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

organonitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

primary amino compound biosynthetic process [inference]

serotonin biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process

cellular aromatic compound metabolic process [inference]

aromatic amino acid metabolic process

phenol-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

aromatic compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

aromatic compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

primary metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process

organic cyclic compound metabolic process [inference]

aromatic amino acid metabolic process

phenol-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

organic cyclic compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

primary amino compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

primary amino compound biosynthetic process [inference]

serotonin biosynthetic process

organonitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

primary amino compound biosynthetic process [inference]

serotonin biosynthetic process

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

organonitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

primary amino compound biosynthetic process [inference]

serotonin biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular process [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process

cellular aromatic compound metabolic process [inference]

aromatic amino acid metabolic process

phenol-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

aromatic compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular nitrogen compound metabolic process [inference]

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular biosynthetic process [inference]

heterocycle biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

aromatic compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

phenol-containing compound biosynthetic process [inference]

serotonin biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

indole-containing compound metabolic process [inference]

serotonin metabolic process [inference]

serotonin biosynthetic process

indole-containing compound biosynthetic process [inference]

serotonin biosynthetic process

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

multicellular organismal process [inference]

tissue remodeling [inference]

bone remodeling

developmental process [inference]

anatomical structure development [inference]

mammary gland alveolus development

rhythmic process [inference]

circadian rhythm

response to stimulus [inference]

response to stress [inference]

response to immobilization stress

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

platelet degranulation

establishment of localization in cell [inference]

platelet degranulation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of ossification

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of cellular process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of fat cell differentiation [inference]

positive regulation of fat cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of fat cell differentiation

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

negative regulation of ossification

negative regulation of multicellular organismal process [inference]

negative regulation of ossification

regulation of hemostasis

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of hemostasis

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	TAS
neuron projection	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

Displaying **all 3** entries
GO Term	Evidence Code	PMID
tryptophan 5-monooxygenase activity	IBA
iron ion binding	IEA
protein binding	IPI	28514442 32296183 32814053 33961781

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [inference]

tryptophan 5-monooxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [inference]

tryptophan 5-monooxygenase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 9** entries
DO ID	Disease Name	Source
DOID:0050742	nicotine dependence	Alliance of Genome Resources
DOID:0060249	scoliosis	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10930	borderline personality disorder	Alliance of Genome Resources
DOID:1094	attention deficit hyperactivity disorder	Alliance of Genome Resources
DOID:1574	alcohol use disorder	Alliance of Genome Resources
DOID:1596	depressive disorder	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources
DOID:9478	postpartum depression	Alliance of Genome Resources

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026