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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
complement C2
Summary
- Gene Symbol
-
- C2
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Age-related macular degeneration
- Alternative splicing
- Complement pathway
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Glycoprotein
- Metal-binding
- Proteomics identification
- Reference proteome
- Repeat
- Secreted
- Serine protease
- Signal
- Sushi
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| proteolysis | ||
| response to bacterium | ||
| response to nutrient | ||
| innate immune response | ||
| response to lipopolysaccharide |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| classical-complement-pathway C3/C5 convertase complex |
|
|
| extracellular space | ||
| extracellular exosome |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| metal ion binding | ||
| serine-type endopeptidase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- Complement factor B
- Functional Category
-
- E: Amino acid transport and metabolism
- Q: Secondary metabolites biosynthesis, transport and catabolism
- T: Signal transduction mechanisms
| InterPro |
|---|
| Sushi/SCR/CCP domain |
| Sushi/SCR/CCP superfamily |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060295 | complement component 2 deficiency | |
| DOID:0110026 | age related macular degeneration 14 | |
| DOID:10652 | Alzheimer's disease | |
| DOID:1407 | anterior uveitis | |
| DOID:4448 | macular degeneration | |
| DOID:8893 | psoriasis | |
| DOID:9074 | systemic lupus erythematosus |
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 12263 | MGI:88226 | MOUSE20465 | ||
| 24231 | RGD:2231 | RATNO22658 | ||
| 294257 | RATNO22658 | |||
| 474853 | CANLF02575 | |||
| 494140 | PANTR37756 | |||
| 497244 | CIOIN03737 | |||
| 515440 | BOVIN18747 | |||
| 563828 | ZFIN:ZDB-GENE-110411-261 | |||
| 716809 | MACMU35126 | |||
| 734198 | Xenbase:XB-GENE-865146 |
