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Guidelines

MIRAGE

complement C2

Summary

Gene Symbol

C2

Organism

Homo sapiens (human)

External Links

NCBI Gene

717

PubChem

717

Alliance of Genome Resources

HGNC:1248

JoGo

C2

TogoVar

C2

Annotation

Keyword

3D-structure
Age-related macular degeneration
Alternative splicing
Complement pathway
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Metal-binding
Proteomics identification
Reference proteome
Repeat
Secreted
Serine protease
Signal
Sushi

Proteins

Displaying **all 7** entries
UniProt	Protein Name
P06681	C3/C5 convertase
Q5JP69	C3/C5 convertase
B4DQI1
Q53HP3	C3/C5 convertase
A0A0G2JL69	C3/C5 convertase
B4DV48	C3/C5 convertase
Q8N6L6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
proteolysis	IEA
complement activation	IMP	19302245
complement activation	IBA
complement activation, classical pathway	IEA
response to nutrient	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

complement activation, classical pathway

activation of immune response [inference]

complement activation

complement activation, classical pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, classical pathway

innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, classical pathway

innate immune response

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response

response to endogenous stimulus [inference]

response to hormone [inference]

response to thyroid hormone

response to chemical [inference]

response to nutrient

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to hormone [inference]

response to thyroid hormone

response to lipid [inference]

response to lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

positive regulation of apoptotic cell clearance

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	TAS	8621452
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	IEA
protein binding	IPI	25910212 28742139 32296183
metal ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

complement factor B

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
complement activation
proteolysis
serine-type endopeptidase activity

Displaying **all 9** entries
InterPro
Complement B/C2
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Sushi/SCR/CCP domain
von Willebrand factor A-like domain superfamily
von Willebrand factor, type A

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060295	complement component 2 deficiency	Alliance of Genome Resources
DOID:0110026	age related macular degeneration 14	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:4448	macular degeneration	Alliance of Genome Resources
DOID:8893	psoriasis	Alliance of Genome Resources

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026