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complement C3

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

718

PubChem

718

Alliance of Genome Resources

HGNC:1318

Annotation

Keyword

3D-structure
Age-related macular degeneration
Cleavage on pair of basic residues
Complement alternate pathway
Complement pathway
Direct protein sequencing
Disease variant
Disulfide bond
Fatty acid metabolism
Glycoprotein
Hemolytic uremic syndrome
Inflammatory response
Phosphoprotein
Reference proteome
Secreted
Signal
Thioester bond

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B4DR57
P01024	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
V9HWA9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
positive regulation of type IIa hypersensitivity	IEA
positive regulation of protein phosphorylation	IDA	15833747
positive regulation of activation of membrane attack complex	IEA
complement receptor mediated signaling pathway	IEA
fatty acid metabolic process	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement activation

immune response

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, alternative pathway

leukocyte activation [inference]

lymphocyte activation [inference]

B cell activation

metabolic process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

B cell activation

cell killing [inference]

complement-dependent cytotoxicity

signal transduction

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

G protein-coupled receptor signaling pathway

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

cellular developmental process [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

cell junction disassembly [inference]

synapse pruning [inference]

complement-mediated synapse pruning

cell junction organization [inference]

synapse organization [inference]

synapse pruning [inference]

complement-mediated synapse pruning

cell junction disassembly [inference]

synapse pruning [inference]

complement-mediated synapse pruning

reproductive process [inference]

developmental process involved in reproduction [inference]

oviduct epithelium development

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

B cell activation

pattern specification process [inference]

regionalization [inference]

vertebrate eye-specific patterning

amyloid-beta clearance

developmental process [inference]

developmental process involved in reproduction [inference]

oviduct epithelium development

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

oviduct epithelium development

cellular developmental process [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

immune response

humoral immune response [inference]

complement activation

innate immune response [inference]

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement activation

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of lymphocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of B cell mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of type II hypersensitivity [inference]

regulation of type IIa hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of type II hypersensitivity [inference]

regulation of type IIa hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

positive regulation of activation of membrane attack complex

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of B cell mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of type II hypersensitivity [inference]

regulation of type IIa hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of hypersensitivity [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of type II hypersensitivity [inference]

regulation of type IIa hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of humoral immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

positive regulation of activation of membrane attack complex

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement activation

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of triglyceride biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of triglyceride biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of lipid biosynthetic process [inference]

regulation of triglyceride biosynthetic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

regulation of localization [inference]

regulation of lipid storage [inference]

positive regulation of lipid storage

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of glucose transmembrane transport [inference]

positive regulation of glucose transmembrane transport

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of phagocytosis [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of phagocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

regulation of phagocytosis, engulfment [inference]

positive regulation of phagocytosis, engulfment

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance

regulation of lipid localization [inference]

positive regulation of lipid localization [inference]

positive regulation of lipid storage

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of myeloid leukocyte mediated immunity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement activation

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of phagocytosis [inference]

positive regulation of membrane invagination [inference]

positive regulation of phagocytosis, engulfment

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement activation

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of phagocytosis [inference]

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of lipid localization [inference]

positive regulation of lipid storage

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of hypersensitivity [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of type II hypersensitivity [inference]

regulation of type IIa hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of hypersensitivity [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of type II hypersensitivity [inference]

regulation of type IIa hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement activation

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of B cell mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of type II hypersensitivity [inference]

regulation of type IIa hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of hypersensitivity [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of type II hypersensitivity [inference]

regulation of type IIa hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of humoral immune response [inference]

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

regulation of complement activation [inference]

regulation of activation of membrane attack complex [inference]

positive regulation of activation of membrane attack complex

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

complement activation

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of humoral immune response [inference]

positive regulation of complement activation [inference]

positive regulation of activation of membrane attack complex

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of hypersensitivity [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of type II hypersensitivity [inference]

regulation of type IIa hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of hypersensitivity [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of type II hypersensitivity [inference]

regulation of type IIa hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

positive regulation of inflammatory response to antigenic stimulus [inference]

positive regulation of acute inflammatory response to antigenic stimulus [inference]

positive regulation of hypersensitivity [inference]

positive regulation of type II hypersensitivity [inference]

positive regulation of type IIa hypersensitivity

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

signal transduction

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

complement receptor mediated signaling pathway

G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of G protein-coupled receptor signaling pathway [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of triglyceride biosynthetic process

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

regulation of triglyceride metabolic process [inference]

regulation of triglyceride biosynthetic process

regulation of transmembrane transport [inference]

regulation of glucose transmembrane transport [inference]

positive regulation of glucose transmembrane transport

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of G protein-coupled receptor signaling pathway

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of transmembrane transport [inference]

positive regulation of glucose transmembrane transport

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of phagocytosis [inference]

positive regulation of membrane invagination [inference]

positive regulation of phagocytosis, engulfment

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of phagocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

regulation of phagocytosis, engulfment [inference]

positive regulation of phagocytosis, engulfment

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of phagocytosis [inference]

positive regulation of membrane invagination [inference]

positive regulation of phagocytosis, engulfment

regulation of membrane invagination [inference]

regulation of phagocytosis, engulfment [inference]

positive regulation of phagocytosis, engulfment

positive regulation of membrane invagination [inference]

positive regulation of phagocytosis, engulfment

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of receptor-mediated endocytosis

positive regulation of phagocytosis [inference]

regulation of receptor-mediated endocytosis [inference]

positive regulation of receptor-mediated endocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis [inference]

regulation of phagocytosis, engulfment [inference]

positive regulation of phagocytosis, engulfment

regulation of apoptotic cell clearance [inference]

positive regulation of apoptotic cell clearance

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

regulation of vascular endothelial growth factor production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of vascular endothelial growth factor production

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular space	IDA	25645918
extracellular space	IBA
extracellular space	HDA	16502470 23580065
endoplasmic reticulum lumen	TAS

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

endoplasmic reticulum lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen

azurophil granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endopeptidase inhibitor activity	IEA
signaling receptor binding	TAS	9164946
protein binding	IPI	11387479 11705926 12438350 12540846 16530040 16612335 17051150 18796626 19255449 20042240 21317894 21527715 21979047 22518841 23086448 24260121 26627825 27814381 28671664 32034129 32296183 33961781 37207277 7483825
C5L2 anaphylatoxin chemotactic receptor binding	IDA	15833747
receptor ligand activity	IDA	21527715

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

G protein-coupled receptor binding [inference]

C5a anaphylatoxin chemotactic receptor binding [inference]

C5L2 anaphylatoxin chemotactic receptor binding

receptor ligand activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Alpha-2-macroglobulin

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying 1 entry
Gene Ontology
endopeptidase inhibitor activity

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InterPro
Alpha-2-macroglobulin, bait region domain
Alpha-2-macroglobulin, conserved site
Alpha-2-macroglobulin
Alpha-macroglobulin, receptor-binding domain superfamily
Alpha-macroglobulin, receptor-binding
Alpha-macroglobulin-like, TED domain
Alpha-macroglobulin-like, thiol-ester bond-forming region
Immunoglobulin-like fold
Macroglobulin domain MG3
Macroglobulin domain

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0060284	paroxysmal nocturnal hemoglobinuria	Alliance of Genome Resources
DOID:0080301	atypical hemolytic-uremic syndrome	Alliance of Genome Resources
DOID:0080600	COVID-19	Alliance of Genome Resources
DOID:0110019	age related macular degeneration 7	Alliance of Genome Resources
DOID:0110021	age related macular degeneration 9	Alliance of Genome Resources
DOID:10325	silicosis	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:10873	Kuhnt-Junius degeneration	Alliance of Genome Resources
DOID:10923	sickle cell anemia	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	718	Xenbase:XB-GENE-486274
Drosophila melanogaster	727	FB:FBgn0267488
Mus musculus	12266	Xenbase:XB-GENE-486274	MOUSE20351
Drosophila melanogaster	15139	FB:FBgn0267488
Rattus norvegicus	24232	Xenbase:XB-GENE-486274	RATNO43749
Danio rerio	30491		DANRE18100
Bos taurus	280677		BOVIN32790
Danio rerio	321046		DANRE17781
Sus scrofa	397072		PIGXX18686
Canis lupus familiaris	476728		CANLF07957

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements