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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Complement C3
Summary
- UniProt ID
- P01024
- Gene Symbol
-
- C3
- CPAMD1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Age-related macular degeneration
- Cleavage on pair of basic residues
- Complement alternate pathway
- Complement pathway
- Direct protein sequencing
- Disease variant
- Disulfide bond
- Fatty acid metabolism
- Glycoprotein
- Hemolytic uremic syndrome
- Inflammatory response
- Phosphoprotein
- Reference proteome
- Secreted
- Signal
- Thioester bond
- Gene Ontology (GO)
| GO Term |
|---|
| signaling receptor binding |
| C5L2 anaphylatoxin chemotactic receptor binding |
| endopeptidase inhibitor activity |
Sequence
MGPTSGPSLLLLLLTHLPLALGSPMYSIITPNILRLESEETMVLEAHDAQGDVPVTVTVHDFPGKKLVLSSEKTVLTPATNHMGNVTFTIPANREFKSEKGRNKFVTVQATFGTQVVEKVVLVSLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSLSSQNQLGVLPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTEKFYYIYNEKGLEVTITARFLYGKKVEGTAFVIFGIQDGEQRISLPESLKRIPIEDGSGEVVLSRKVLLDGVQNPRAEDLVGKSLYVSATVILHSGSDMVQAERSGIPIVTSPYQIHFTKTPKYFKPGMPFDLMVFVTNPDGSPAYRVPVAVQGEDTVQSLTQGDGVAKLSINTHPSQKPLSITVRTKKQELSEAEQATRTMQALPYSTVGNSNNYLHLSVLRTELRPGETLNVNFLLRMDRAHEAKIRYYTYLIMNKGRLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLVAYYTLIGASGQREVVADSVWVDVKDSCVGSLVVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKDYAGVFSDAGLTFTSSSGQQTAQRAELQCPQPAARRRRSVQLTEKRMDKVGKYPKELRKCCEDGMRENPMRFSCQRRTRFISLGEACKKVFLDCCNYITELRRQHARASHLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLMNIFLKDSITTWEILAVSMSDKKGICVADPFEVTVMQDFFIDLRLPYSVVRNEQVEIRAVLYNYRQNQELKVRVELLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQEVEVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAVRTLDPERLGREGVQKEDIPPADLSDQVPDTESETRILLQGTPVAQMTEDAVDAERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDETEQWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKRAPSTWLTAYVVKVFSLAVNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISLQEAKDICEEQVNSLPGSITKAGDFLEANYMNLQRSYTVAIAGYALAQMGRLKGPLLNKFLTTAKDKNRWEDPGKQLYNVEATSYALLALLQLKDFDFVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESASLLRSEETKENEGFTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAPETEKRPQDAKNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDKAFSDRNTLIIYLDKVSHSEDDCLAFKVHQYFNVELIQPGAVKVYAYYNLEESCTRFYHPEKEDGKLNKLCRDELCRCAEENCFIQKSDDKVTLEERLDKACEPGVDYVYKTRLVKVQLSNDFDEYIMAIEQTIKSGSDEVQVGQQRTFISPIKCREALKLEEKKHYLMWGLSSDFWGEKPNLSYIIGKDTWVEHWPEEDECQDEENQKQCQDLGAFTESMVVFGCPN
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 85 | N-linked (GlcNAc...) asparagine |
|
||
| 939 | N-linked (GlcNAc...) asparagine | |||
| 985 |
|
|||
| 1617 | N-linked (GlcNAc...) asparagine | |||
|
|
G11115RO
G99679NM
G20312EM
G68490OW
G94470IW
G14972EH
G26330YA
G00912UN
G48414YA
G92551JA
G70441OD
G87661QW
G83646BJ
G96430BV
G36442WJ
G17208MA
G76295SF
G15664MX
G46691LC
G34029GR
G85582CB
G83460ZZ
G96091TT
G49018RC
G72747WU
G70619PT
G59626AS
G73430PD
G92406TI
G46503DX
G41840AI
G01650EU
G23294PN
G61302NC
G70101JE
G80920RR
G34730YF
G63041LO
G67324HN
G65184UU
G42124LM
G02886BB
G90659AW
G65000LJ
G29299MO
G37399XV
G82463GQ
G14260UH
G62765YT
G64527OM
G66676MI
G72790NZ
G95177YH
G10486CT
G05049YU
G28541PG
G72735IY
G05724UK
G31852PQ
G70160EA
G82020ZR
G90575OW
G72787SB
G23719VF
G33609NS
G39446WN
G10471FG
G39188ZX
G41247ZX
G80966KZ
G50282JC
G23453IV
G57776ZU
G02815KT
G06110VR
G32104JU
G55220VL
G84349RE
G57317CE
G60145BJ
G66538GV
G92050GC
G28681TP
G31544HA
G30769VJ
G86234IN
G90093AU
G70375MX
G78790NZ
G72398FA
G43417UB
G69834CE
G95678HJ
G49955PK
G40702WU
G68668TB
G83161QT
G49108TO
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of C3 and C5 | Homo sapiens |
| Alternative complement activation | Homo sapiens |
| G alpha (i) signalling events | Homo sapiens |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | Homo sapiens |
| Neutrophil degranulation | Homo sapiens |
| Peptide ligand-binding receptors | Homo sapiens |
| Post-translational protein phosphorylation | Homo sapiens |
| Purinergic signaling in leishmaniasis infection | Homo sapiens |
| Regulation of Complement cascade | Homo sapiens |
| Regulation of IGF Activity by IGFBP | Homo sapiens |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
