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Guidelines

MIRAGE

transthyretin

Summary

Gene Symbol

TTR

Organism

Homo sapiens (human)

External Links

NCBI Gene

7276

PubChem

7276

Alliance of Genome Resources

HGNC:12405

Annotation

Keyword

3D-structure
Amyloid
Amyloidosis
Cytoplasm
Direct protein sequencing
Disease variant
Gamma-carboxyglutamic acid
Glycoprotein
Neuropathy
Phosphoprotein
Reference proteome
Secreted
Signal
Sulfation
Thyroid hormone
Transport

Proteins

Displaying **all 2** entries
UniProt	Protein Name
E9KL36
P02766	ATTR Prealbumin TBPA

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
retinoid metabolic process	IEA
negative regulation of glomerular filtration	IEA
purine nucleobase metabolic process	IBA
phototransduction, visible light	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

organonitrogen compound metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

organonitrogen compound metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

cellular process [inference]

signal transduction [inference]

phototransduction [inference]

phototransduction, visible light

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleobase metabolic process [inference]

purine nucleobase metabolic process

purine-containing compound metabolic process [inference]

purine nucleobase metabolic process

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal system process involved in regulation of systemic arterial blood pressure [inference]

renal system process involved in regulation of blood volume [inference]

regulation of glomerular filtration [inference]

negative regulation of glomerular filtration

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

phototransduction, visible light

detection of visible light [inference]

phototransduction, visible light

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

phototransduction, visible light

detection of visible light [inference]

phototransduction, visible light

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

phototransduction, visible light

detection of visible light [inference]

phototransduction, visible light

detection of stimulus [inference]

detection of external stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

phototransduction, visible light

detection of visible light [inference]

phototransduction, visible light

detection of abiotic stimulus [inference]

detection of light stimulus [inference]

phototransduction [inference]

phototransduction, visible light

detection of visible light [inference]

phototransduction, visible light

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of glomerular filtration

regulation of cellular process [inference]

signal transduction [inference]

phototransduction [inference]

phototransduction, visible light

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of renal system process [inference]

regulation of glomerular filtration [inference]

negative regulation of glomerular filtration

negative regulation of multicellular organismal process [inference]

negative regulation of glomerular filtration

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	NAS	14718574
extracellular region	TAS
extracellular space	IBA
extracellular space	HDA	16502470
azurophil granule lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

intracellular organelle lumen [inference]

vacuolar lumen [inference]

azurophil granule lumen

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

azurophil granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
hormone activity	IEA
protein binding	IPI	16189514 16716307 18272491 20646067 21777382 21900206 25416956 29892012 29997244 30213975 31515488 32296183 32814053 33961781 986177
identical protein binding	IPI	19861125 21422279 21740906 21777382 23792159 23850452
thyroid hormone binding
molecular sequestering activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor ligand activity [inference]

hormone activity

identical protein binding

hormone binding [inference]

thyroid hormone binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

hormone activity

molecular sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Transthyretin

Functional Category

F: Nucleotide transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
hormone activity
purine nucleobase metabolic process
thyroid hormone binding

Displaying **all 5** entries
InterPro
Transthyretin, conserved site
Transthyretin, thyroxine binding site
Transthyretin/hydroxyisourate hydrolase domain superfamily
Transthyretin/hydroxyisourate hydrolase domain
Transthyretin/hydroxyisourate hydrolase

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0050638	transthyretin amyloidosis	Alliance of Genome Resources
DOID:0070466	carpal tunnel syndrome 1	Alliance of Genome Resources
DOID:0080219	dystransthyretinemic hyperthyroxinemia	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:9120	amyloidosis	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 84 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Monodelphis domestica	497043		MONDO17646
Macaca mulatta	705943		MACMU17389
Equus caballus	100052147		HORSE42152
Ornithorhynchus anatinus	100079789		ORNAN24689
Pongo abelii	100174094		PONAB13506
Taeniopygia guttata	100190720		TAEGU18034
Oryctolagus cuniculus	100347317		RABIT13132
Callithrix jacchus	100414809		CALJA08441
Ailuropoda melanoleuca	100467689		AILME05105
Anolis carolinensis	100561897		ANOCA17438

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Last updated: December 8, 2025