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mono-ADP ribosylhydrolase 2

Summary

Gene Symbol

Macrod2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

72899

PubChem

72899

Alliance of Genome Resources

MGI:1920149

Annotation

Keyword

DNA damage
Hydrolase
Isopeptide bond
Nucleus
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3UYG8	MACRO domain-containing protein 2 O-acetyl-ADP-ribose deacetylase MACROD2 [Protein ADP-ribosylaspartate] hydrolase MACROD2 [Protein ADP-ribosylglutamate] hydrolase MACROD2
Q9D117

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 7** of 7 in total

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2
GO Term	Evidence Code	PMID
protein de-ADP-ribosylation	ISO
DNA damage response	IBA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

organonitrogen compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

macromolecule modification [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

organonitrogen compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleus	ISO
nucleolus	ISO
nucleoplasm	IBA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
hydrolase activity	IEA
hydrolase activity, acting on glycosyl bonds	ISO
O-acetyl-ADP-ribose deacetylase activity
ADP-ribosylglutamate hydrolase activity	IBA ISO
deacetylase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

ADP-ribosylglutamate hydrolase activity

deacetylase activity

O-acetyl-ADP-ribose deacetylase activity

catalytic activity, acting on a protein [inference]

ADP-ribosylglutamate hydrolase activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying **all 8** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	178044	WB:WBGene00007106
Danio rerio	393521	ZFIN:ZDB-GENE-040426-1490
Macaca mulatta	694547		MACMU01095
Homo sapiens	140733	HGNC:16126
Balaenoptera musculus	118881781		BALMU20737
Dipodomys ordii	105981728		DIPOR03424
Bos indicus x Bos taurus	113903711		BOBOX03635
Chinchilla lanigera	102004066		CHILA04950