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mono-ADP ribosylhydrolase 2

Summary

Gene Symbol

Macrod2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

72899

PubChem

72899

Alliance of Genome Resources

MGI:1920149

Annotation

Keyword

DNA damage
Hydrolase
Isopeptide bond
Nucleus
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3UYG8	MACRO domain-containing protein 2 O-acetyl-ADP-ribose deacetylase MACROD2 [Protein ADP-ribosylaspartate] hydrolase MACROD2 [Protein ADP-ribosylglutamate] hydrolase MACROD2
Q9D117

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
cellular response to DNA damage stimulus	ISS
DNA damage response	ISS
cellular response to DNA damage stimulus	ISO
DNA damage response	ISO
cellular response to DNA damage stimulus	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

organonitrogen compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

macromolecule modification [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

carbohydrate derivative metabolic process [inference]

glycosyl compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

organonitrogen compound metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein de-ADP-ribosylation

peptidyl-glutamate ADP-deribosylation

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

purine nucleoside metabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	ISO
nucleoplasm	ISO
nucleoplasm	IBA
nucleoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
hydrolase activity, acting on glycosyl bonds	ISS
hydrolase activity, acting on glycosyl bonds	ISO
deacetylase activity	ISO
O-acetyl-ADP-ribose deacetylase activity	IEA
ADP-ribosylglutamate hydrolase activity	ISS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

ADP-ribosylglutamate hydrolase activity

deacetylase activity

O-acetyl-ADP-ribose deacetylase activity

catalytic activity, acting on a protein [inference]

ADP-ribosylglutamate hydrolase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

macro domain-containing protein

Functional Category

E: Amino acid transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
InterPro
Macro domain-like
Macro domain

Ortholog

Displaying entries **1 - 10** of 11 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	28992	WB:WBGene00007106
Danio rerio	72899	ZFIN:ZDB-GENE-040426-1490
Caenorhabditis elegans	107227	WB:WBGene00007106
Danio rerio	140733	ZFIN:ZDB-GENE-040426-1490
Caenorhabditis elegans	246233	WB:WBGene00007106
Homo sapiens	398781	HGNC:16126
Macaca mulatta	694547		MACMU01095
Chinchilla lanigera	102004066		CHILA04950
Dipodomys ordii	105981728		DIPOR03424
Bos indicus x Bos taurus	113903711		BOBOX03635