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complement C8 beta chain

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

732

PubChem

732

Alliance of Genome Resources

HGNC:1353

Annotation

Keyword

3D-structure
Complement alternate pathway
Direct protein sequencing
Disulfide bond
EGF-like domain
Glycoprotein
Membrane attack complex
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B7Z550	Complement component 8 subunit beta
P07358	Complement component 8 subunit beta
B7Z555	Complement component 8 subunit beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
immune response	TAS	8098723
complement activation	IBA
complement activation, alternative pathway	IEA
complement activation, classical pathway	IEA
killing of cells of another organism	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response

humoral immune response [inference]

complement activation

innate immune response

complement activation, alternative pathway

cellular process [inference]

cell killing [inference]

killing of cells of another organism

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

complement activation, alternative pathway

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

complement activation, alternative pathway

immune response

humoral immune response [inference]

complement activation

innate immune response

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

complement activation, alternative pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

complement activation, alternative pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
membrane attack complex	IDA	22832194
membrane attack complex	IBA
membrane attack complex	IPI	30552328
extracellular space	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex [inference]

membrane attack complex

plasma membrane protein complex [inference]

membrane attack complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

Displaying 1 entry
GO Term	Evidence Code	PMID
protein-containing complex binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

complement component c8 beta chain

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 4** entries
Gene Ontology
complement activation, classical pathway
complement activation
immune response
immune system process

Displaying **all 9** entries
InterPro
Complement components C8A/B/C6, EGF-like domain
LDL receptor-like superfamily
Low-density lipoprotein (LDL) receptor class A repeat
Low-density lipoprotein (LDL) receptor class A, conserved site
Membrane attack complex component/perforin (MACPF) domain
Membrane attack complex component/perforin domain, conserved site
Membrane attack complex component/perforin/complement C9
Thrombospondin type-1 (TSP1) repeat superfamily
Thrombospondin type-1 (TSP1) repeat

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060302	type II complement component 8 deficiency	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 67 in total

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Species	Gene ID	Orthologous MAtrix
Ficedula albicollis	101814170	FICAL08621
Chrysemys picta bellii	101939780	CHRPI04283
Ictidomys tridecemlineatus	101956560	ICTTR15066
Capra hircus	102170749	CAPHI21794
Latimeria chalumnae	102346549	LATCH10421
Myotis lucifugus	102435040	MYOLU09780
Pelodiscus sinensis	102453356	PELSI14713
Erinaceus europaeus	103109020	ERIEU14387
Callorhinchus milii	103185299	CALMI31835
Chlorocebus sabaeus	103224737	CHLSB08835

GlyTouCan

GlyComb

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UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements