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vimentin

Summary

Gene Symbol

Organism

Homo sapiens (human)

External Links

NCBI Gene

7431

PubChem

7431

Alliance of Genome Resources

HGNC:12692

Annotation

Keyword

3D-structure
Acetylation
Cataract
Cell membrane
Cell projection
Coiled coil
Cytoskeleton
Direct protein sequencing
Disease variant
Glycoprotein
Host-virus interaction
Intermediate filament
Isopeptide bond
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
S-nitrosylation
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
V9HWE1
P08670

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
positive regulation of gene expression	IEA
negative regulation of neuron projection development	IEA
astrocyte development	IEA
neuron projection development	IEA
positive regulation of collagen biosynthetic process	IMP	21746880

GO Hierarchy

biological process

cellular process [inference]

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

astrocyte differentiation [inference]

Bergmann glial cell differentiation

cell development [inference]

epithelial cell development [inference]

lens fiber cell development

glial cell development [inference]

astrocyte development

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to muramyl dipeptide

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to muramyl dipeptide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to peptide [inference]

cellular response to muramyl dipeptide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

supramolecular fiber organization [inference]

intermediate filament organization

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

epithelial cell development [inference]

lens fiber cell development

glial cell development [inference]

astrocyte development

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

astrocyte differentiation [inference]

Bergmann glial cell differentiation

cell development [inference]

epithelial cell development [inference]

lens fiber cell development

glial cell development [inference]

astrocyte development

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to muramyl dipeptide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to muramyl dipeptide

response to peptide [inference]

response to muramyl dipeptide [inference]

cellular response to muramyl dipeptide

cellular response to peptide [inference]

cellular response to muramyl dipeptide

response to lipid [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to lipid [inference]

cellular response to lipopolysaccharide

response to cytokine [inference]

response to type II interferon [inference]

cellular response to type II interferon

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to muramyl dipeptide

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to muramyl dipeptide

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to muramyl dipeptide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to peptide [inference]

cellular response to muramyl dipeptide

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to muramyl dipeptide

response to peptide [inference]

response to muramyl dipeptide [inference]

cellular response to muramyl dipeptide

cellular response to peptide [inference]

cellular response to muramyl dipeptide

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to muramyl dipeptide

response to oxygen-containing compound [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

response to peptide [inference]

response to muramyl dipeptide [inference]

cellular response to muramyl dipeptide

cellular response to peptide [inference]

cellular response to muramyl dipeptide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to peptide [inference]

cellular response to muramyl dipeptide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to type II interferon

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to muramyl dipeptide

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to peptide [inference]

cellular response to muramyl dipeptide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to peptide [inference]

cellular response to muramyl dipeptide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of collagen biosynthetic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

positive regulation of gene expression

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of collagen biosynthetic process [inference]

positive regulation of collagen biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of collagen biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of collagen metabolic process [inference]

positive regulation of collagen biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of catabolic process [inference]

regulation of cellular catabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of collagen metabolic process [inference]

positive regulation of collagen metabolic process [inference]

positive regulation of collagen biosynthetic process

regulation of collagen biosynthetic process [inference]

positive regulation of collagen biosynthetic process

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

positive regulation of gene expression

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular catabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

positive regulation of gene expression

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of collagen biosynthetic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of collagen metabolic process [inference]

positive regulation of collagen biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

positive regulation of gene expression

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular catabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

regulation of mRNA catabolic process [inference]

regulation of mRNA stability

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

negative regulation of cellular process [inference]

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

negative regulation of neuron projection development

negative regulation of cellular component organization [inference]

negative regulation of cell projection organization [inference]

negative regulation of neuron projection development

regulation of biological quality [inference]

regulation of RNA stability [inference]

regulation of mRNA stability

Displaying entries **6 - 10** of 19 in total

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GO Term	Evidence Code	PMID
cytosol	IDA	21746880
cytoskeleton	TAS	16130169
cytoskeleton	IDA	16769727
intermediate filament	IDA	11889032 29496907
intermediate filament	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

nuclear matrix

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

cell leading edge

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intermediate filament cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
double-stranded RNA binding	IDA	21266579
structural constituent of cytoskeleton	IDA	11889032
structural constituent of cytoskeleton	IBA
structural constituent of eye lens	IEA
protein binding	IPI	10852826 11827972 15161933 15383276 15671067 15846844 16169070 16189514 16361107 16712842 16923132 17056548 18811945 18827015 19386766 19420356 20603131 20618440 20729920 20856200 21699783 21900206 22300583 22684479 23112296 24284321 24940650 25218743 25416956 25959826 26496610 27107012 27173435 27229929 27812135 28514442 29477555 30021884 31515488 31911079 31980649 32296183 32814053 33961781 35078919 35271311 35273242 36217029 36217030 36931259

GO Hierarchy

molecular function

structural molecule activity [inference]

binding [inference]

protein binding

intermediate filament binding [inference]

keratin filament binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

double-stranded RNA binding

molecular adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

internexin neuronal intermediate filament protein, alpha a

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
intermediate filament organization
structural constituent of cytoskeleton

Displaying **all 3** entries
InterPro
Intermediate filament head, DNA-binding domain
Intermediate filament protein, conserved site
Intermediate filament, rod domain

Disease

Disease Ontology

Displaying **all 6** entries
DO ID	Disease Name	Source
DOID:0110248	cataract 30	Alliance of Genome Resources
DOID:12894	Sjogren's syndrome	Alliance of Genome Resources
DOID:13241	Behcet's disease	Alliance of Genome Resources
DOID:1936	atherosclerosis	Alliance of Genome Resources
DOID:7148	rheumatoid arthritis	Alliance of Genome Resources
DOID:9074	systemic lupus erythematosus	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements