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diacylglycerol lipase alpha

Summary

Gene Symbol

DAGLA

Aliases

DAGLALPHA
KIAA0659
NSDDR
neural stem cell-derived dendrite regulator

Organism

Homo sapiens (human)

External Links

NCBI Gene

747

HGNC

1165

PubChem

747

Alliance of Genome Resources

HGNC:1165

Annotation

Keyword

Calcium
Cell membrane
Cell projection
Disease variant
Endosome
Glycoprotein
Hydrolase
Intellectual disability
Lipid degradation
Metal-binding
Phosphoprotein
Postsynaptic cell membrane
Proteomics identification
Reference proteome
Spinocerebellar ataxia
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y4D2	Neural stem cell-derived dendrite regulator Sn1-specific diacylglycerol lipase alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
monoacylglycerol biosynthetic process	IEA
neuroblast proliferation	IEA
arachidonic acid metabolic process	TAS
arachidonic acid metabolic process	IDA	14610053
arachidonic acid metabolic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

cannabinoid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

olefinic compound metabolic process [inference]

arachidonic acid metabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

cannabinoid biosynthetic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

retrograde trans-synaptic signaling [inference]

retrograde trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by endocannabinoid

trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by endocannabinoid

trans-synaptic signaling by endocannabinoid [inference]

retrograde trans-synaptic signaling by endocannabinoid

cell population proliferation [inference]

neural precursor cell proliferation [inference]

neuroblast proliferation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

retrograde trans-synaptic signaling [inference]

retrograde trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by endocannabinoid

trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by endocannabinoid

trans-synaptic signaling by endocannabinoid [inference]

retrograde trans-synaptic signaling by endocannabinoid

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of inflammatory response [inference]

regulation of neuroinflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response [inference]

regulation of neuroinflammatory response

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
plasma membrane	TAS
early endosome membrane	IDA	27595600
dendrite membrane	IDA	27595600
dendrite membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

early endosome membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

leading edge membrane [inference]

neuron projection membrane [inference]

varicosity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
lipoprotein lipase activity	IBA
protein binding	IPI	23502535 32296183
metal ion binding	IEA
acylglycerol lipase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

triglyceride lipase activity [inference]

lipoprotein lipase activity

acylglycerol lipase activity

carboxylic ester hydrolase activity [inference]

triglyceride lipase activity [inference]

lipoprotein lipase activity

acylglycerol lipase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

lipase

Functional Category

I: Lipid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
arachidonic acid metabolic process
diacylglycerol catabolic process
lipid metabolic process
lipoprotein lipase activity
retrograde trans-synaptic signaling by endocannabinoid

Displaying **all 2** entries
InterPro
Alpha/Beta hydrolase fold
Fungal lipase-like domain

Rhea

RHEA:33275

H₂O + a 1,2-diacyl-sn-glycerol

H⁺ + a 2-acylglycerol + a fatty acid

Enzyme

3.1.1.116

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1324	lung cancer	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003827
Gene Name: diacylglycerol lipase, alpha

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements