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Guidelines

MIRAGE

diacylglycerol lipase alpha

Summary

Gene Symbol

DAGLA

Aliases

DAGLALPHA
KIAA0659
NSDDR
neural stem cell-derived dendrite regulator

Organism

Homo sapiens (human)

External Links

NCBI Gene

747

HGNC

1165

PubChem

747

Alliance of Genome Resources

HGNC:1165

JoGo

DAGLA

TogoVar

DAGLA

Annotation

Keyword

Calcium
Cell membrane
Cell projection
Disease variant
Endosome
Glycoprotein
Hydrolase
Intellectual disability
Lipid degradation
Metal-binding
Phosphoprotein
Postsynaptic cell membrane
Proteomics identification
Reference proteome
Spinocerebellar ataxia
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y4D2	Neural stem cell-derived dendrite regulator Sn1-specific diacylglycerol lipase alpha

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 13 in total

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GO Term	Evidence Code	PMID
diacylglycerol catabolic process	IDA	14610053
diacylglycerol catabolic process	IMP	23502535
diacylglycerol catabolic process	IBA
retrograde trans-synaptic signaling by endocannabinoid	ISS
retrograde trans-synaptic signaling by endocannabinoid	IMP	23502535

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

cannabinoid biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

olefinic compound metabolic process [inference]

arachidonic acid metabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

cannabinoid biosynthetic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

retrograde trans-synaptic signaling [inference]

retrograde trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by endocannabinoid

trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by endocannabinoid

trans-synaptic signaling by endocannabinoid [inference]

retrograde trans-synaptic signaling by endocannabinoid

cell population proliferation [inference]

neural precursor cell proliferation [inference]

neuroblast proliferation

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

cellular lipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

monoacylglycerol metabolic process [inference]

monoacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

monoacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

diacylglycerol catabolic process

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

retrograde trans-synaptic signaling [inference]

retrograde trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by endocannabinoid

trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by lipid [inference]

retrograde trans-synaptic signaling by endocannabinoid

trans-synaptic signaling by endocannabinoid [inference]

retrograde trans-synaptic signaling by endocannabinoid

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of inflammatory response [inference]

regulation of neuroinflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of inflammatory response [inference]

regulation of neuroinflammatory response

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
plasma membrane	TAS
early endosome membrane	IDA	27595600
dendrite membrane	IDA	27595600
dendrite membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

early endosome membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

leading edge membrane [inference]

neuron projection membrane [inference]

varicosity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
lipoprotein lipase activity	IBA
protein binding	IPI	23502535 32296183
metal ion binding	IEA
acylglycerol lipase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

triglyceride lipase activity [inference]

lipoprotein lipase activity

acylglycerol lipase activity

carboxylic ester hydrolase activity [inference]

triglyceride lipase activity [inference]

lipoprotein lipase activity

acylglycerol lipase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Rhea

H₂O + a 1,2-diacyl-sn-glycerol

H⁺ + a 2-acylglycerol + a fatty acid

Enzyme

3.1.1.116

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1324	lung cancer	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003827
Gene Name: diacylglycerol lipase, alpha

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026