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Wnt family member 2B

Summary

Gene Symbol

WNT2B

Organism

Homo sapiens (human)

External Links

NCBI Gene

7482

PubChem

7482

Alliance of Genome Resources

HGNC:12781

Annotation

Keyword

Alternative splicing
Developmental protein
Disease variant
Disulfide bond
Extracellular matrix
Glycoprotein
Lipoprotein
Proteomics identification
Reference proteome
Signal
Wnt signaling pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q93097	Protein Wnt-13
Q5TEH8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
neuron differentiation	IBA ISS
positive regulation of branching involved in ureteric bud morphogenesis	IEA
lens development in camera-type eye	ISS	16258938
cornea development in camera-type eye	ISS	16258938
forebrain regionalization	IEP	15164427

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

mesenchymal-epithelial cell signaling

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

cell population proliferation [inference]

stem cell proliferation [inference]

hematopoietic stem cell proliferation

cellular developmental process [inference]

cell differentiation [inference]

cell fate commitment

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

forebrain regionalization

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

anatomical structure morphogenesis [inference]

iris morphogenesis

developmental induction [inference]

organ induction [inference]

lung induction

anatomical structure development [inference]

lens development in camera-type eye

animal organ development [inference]

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

cornea development in camera-type eye

cellular developmental process [inference]

cell differentiation [inference]

cell fate commitment

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to starvation

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

mesenchymal-epithelial cell signaling

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of animal organ morphogenesis [inference]

organ induction [inference]

lung induction

positive regulation of morphogenesis of an epithelium [inference]

positive regulation of branching involved in ureteric bud morphogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of branching involved in ureteric bud morphogenesis

positive regulation of animal organ morphogenesis [inference]

organ induction [inference]

lung induction

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of morphogenesis of a branching structure [inference]

regulation of branching involved in lung morphogenesis [inference]

lung induction

regulation of branching involved in ureteric bud morphogenesis [inference]

positive regulation of branching involved in ureteric bud morphogenesis

regulation of morphogenesis of an epithelium [inference]

regulation of branching involved in lung morphogenesis [inference]

lung induction

regulation of branching involved in ureteric bud morphogenesis [inference]

positive regulation of branching involved in ureteric bud morphogenesis

positive regulation of morphogenesis of an epithelium [inference]

positive regulation of branching involved in ureteric bud morphogenesis

regulation of animal organ morphogenesis [inference]

regulation of animal organ formation [inference]

organ induction [inference]

lung induction

regulation of branching involved in ureteric bud morphogenesis [inference]

positive regulation of branching involved in ureteric bud morphogenesis

positive regulation of animal organ morphogenesis [inference]

organ induction [inference]

lung induction

positive regulation of developmental process [inference]

positive regulation of animal organ morphogenesis [inference]

organ induction [inference]

lung induction

positive regulation of morphogenesis of an epithelium [inference]

positive regulation of branching involved in ureteric bud morphogenesis

regulation of kidney development [inference]

regulation of branching involved in ureteric bud morphogenesis [inference]

positive regulation of branching involved in ureteric bud morphogenesis

regulation of multicellular organismal development [inference]

regulation of embryonic development [inference]

lung induction

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway [inference]

canonical Wnt signaling pathway

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of branching involved in ureteric bud morphogenesis

positive regulation of animal organ morphogenesis [inference]

organ induction [inference]

lung induction

regulation of morphogenesis of a branching structure [inference]

regulation of branching involved in lung morphogenesis [inference]

lung induction

regulation of branching involved in ureteric bud morphogenesis [inference]

positive regulation of branching involved in ureteric bud morphogenesis

regulation of multicellular organismal development [inference]

regulation of embryonic development [inference]

lung induction

Displaying **all 4** entries
GO Term	Evidence Code	PMID
collagen-containing extracellular matrix	HDA	25037231
intracellular membrane-bounded organelle	IDA
extracellular region	TAS
extracellular space	IBA NAS	15135146

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
frizzled binding	IBA
cytokine activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

G protein-coupled receptor binding [inference]

frizzled binding

receptor ligand activity [inference]

cytokine activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Wnt

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
canonical Wnt signaling pathway
cell fate commitment
cytokine activity
neuron differentiation
signaling receptor binding

Displaying **all 3** entries
InterPro
Wnt protein, conserved site
Wnt, C-terminal domain
Wnt

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060774	congenital diarrhea	Alliance of Genome Resources
DOID:1911	endodermal sinus tumor	Alliance of Genome Resources
DOID:3307	teratoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 86 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	22414		MGI:1261834	MOUSE38639
Rattus norvegicus	116466		RGD:69346	RATNO22749
Caenorhabditis elegans	177870		WB:WBGene00000858
Danio rerio	359837		ZFIN:ZDB-GENE-030717-2
Xenopus laevis	378566		Xenbase:XB-GENE-960151
Bos taurus	445420			BOVIN26250
Pan troglodytes	457103	9598_0:00091a		PANTR22019
Danio rerio	556087		ZFIN:ZDB-GENE-060824-6	DANRE45639
Macaca mulatta	705773			MACMU24870
Monodelphis domestica	100033140			MONDO14332