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phospholipase A2 group VII

Summary

Gene Symbol

PLA2G7

Aliases

LDL-PLA2
PAFAH

Organism

Homo sapiens (human)

External Links

NCBI Gene

7941

HGNC

9040

KEGG Gene ID

hsa:7941

PubChem

7941

Alliance of Genome Resources

HGNC:9040

Annotation

Keyword

3D-structure
Asthma
Direct protein sequencing
Disease variant
Glycoprotein
HDL
Hydrolase
LDL
Phospholipid degradation
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q13093	1-alkyl-2-acetylglycerophosphocholine esterase 2-acetyl-1-alkylglycerophosphocholine esterase Group-VIIA phospholipase A2 LDL-associated phospholipase A2 PAF 2-acylhydrolase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

1

2

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GO Term	Evidence Code	PMID
platelet activating factor metabolic process	IDA	10066756 10504265 11590221 8624782
low-density lipoprotein particle remodeling	IDA	8624782
plasma lipoprotein particle oxidation	IDA	8624782
positive regulation of inflammatory response		8624782
lipid oxidation	IDA	8624782

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

platelet activating factor metabolic process

platelet activating factor catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

organonitrogen compound catabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerol ether catabolic process [inference]

platelet activating factor catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

ether catabolic process [inference]

glycerol ether catabolic process [inference]

platelet activating factor catabolic process

organonitrogen compound catabolic process [inference]

hormone metabolic process [inference]

peptide hormone processing

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerol ether catabolic process [inference]

platelet activating factor catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

lipid modification [inference]

lipid oxidation

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

ether lipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

lipid modification [inference]

lipid oxidation

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

ether lipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

small molecule metabolic process [inference]

ether metabolic process [inference]

glycerol ether metabolic process [inference]

glycerol ether catabolic process [inference]

platelet activating factor catabolic process

ether lipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

ether catabolic process [inference]

glycerol ether catabolic process [inference]

platelet activating factor catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

lipid modification [inference]

lipid oxidation

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

ether lipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

ether metabolic process [inference]

glycerol ether metabolic process [inference]

glycerol ether catabolic process [inference]

platelet activating factor catabolic process

ether lipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

ether catabolic process [inference]

glycerol ether catabolic process [inference]

platelet activating factor catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

signaling receptor ligand precursor processing [inference]

peptide hormone processing

platelet activating factor metabolic process

platelet activating factor catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

organonitrogen compound catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

ether catabolic process [inference]

glycerol ether catabolic process [inference]

platelet activating factor catabolic process

organonitrogen compound catabolic process [inference]

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerol ether catabolic process [inference]

platelet activating factor catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

lipid modification [inference]

lipid oxidation

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

ether lipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

platelet activating factor metabolic process

platelet activating factor catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling [inference]

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

multicellular organismal process [inference]

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

positive regulation of locomotion [inference]

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of inflammatory response [inference]

positive regulation of inflammatory response

regulation of chemotaxis [inference]

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response

positive regulation of chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response

regulation of inflammatory response [inference]

positive regulation of inflammatory response

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

regulation of leukocyte chemotaxis [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

regulation of mononuclear cell migration [inference]

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

regulation of monocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of leukocyte migration [inference]

positive regulation of leukocyte chemotaxis [inference]

positive regulation of monocyte chemotaxis

positive regulation of mononuclear cell migration [inference]

positive regulation of monocyte chemotaxis

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying **all 3** entries
GO Term	Evidence Code	PMID
high-density lipoprotein particle	IDA	11590221
extracellular region
low-density lipoprotein particle	IDA	10066756 12821559 8624782

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-lipid complex [inference]

lipoprotein particle [inference]

plasma lipoprotein particle [inference]

cellular anatomical entity [inference]

extracellular region

Displaying **all 4** entries
GO Term	Evidence Code	PMID
calcium-independent phospholipase A2 activity	IDA	2040620 8624782
hydrolase activity, acting on ester bonds
phospholipid binding	IDA	8624782
1-alkyl-2-acetylglycerophosphocholine esterase activity	IBA IDA	10066756 10504265 11590221 16371369 8624782

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds

lipase activity [inference]

phospholipase activity [inference]

phospholipase A2 activity [inference]

calcium-independent phospholipase A2 activity

carboxylic ester hydrolase activity [inference]

1-alkyl-2-acetylglycerophosphocholine esterase activity

phospholipase A2 activity [inference]

calcium-independent phospholipase A2 activity

binding [inference]

lipid binding [inference]

phospholipid binding

Gene Ontology information from NCBI Gene and UniProt.

Rhea

RHEA:17777

H₂O + a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine

H⁺ + acetate + 1-O-alkyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.47

PMID

Disease

Disease Ontology

Displaying entries **111 - 120** of **219** in total

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DO ID	Disease Name	Source
DOID:11984	hypertrophic cardiomyopathy	DisGeNET DisGeNET
DOID:12554	hemolytic-uremic syndrome	DisGeNET Alliance of Genome Resources
DOID:12689	acoustic neuroma	DisGeNET
DOID:12716	newborn respiratory distress syndrome	DisGeNET
DOID:1287	cardiovascular system disease	DisGeNET
DOID:12930	dilated cardiomyopathy	DisGeNET DisGeNET
DOID:12932	endomyocardial fibrosis	DisGeNET
DOID:13001	carotid stenosis	DisGeNET DisGeNET Alliance of Genome Resources
DOID:13003	vertebrobasilar insufficiency	DisGeNET DisGeNET
DOID:1307	dementia	DisGeNET Alliance of Genome Resources