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Guidelines

MIRAGE

cholesterol 25-hydroxylase like 1, tandem duplicate 2

Summary

Gene Symbol

ch25hl1.2

Organism

Danio rerio (zebrafish)

External Links

NCBI Gene

798384

PubChem

798384

Alliance of Genome Resources

ZFIN:ZDB-GENE-050419-90

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Iron
Metal-binding
Monooxygenase
Reference proteome
Sterol biosynthesis
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A223M0M0
Q1LX59

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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2

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GO Term	Evidence Code	PMID
lipid metabolic process	IEA
steroid biosynthetic process	IEA
steroid metabolic process	IEA
cholesterol metabolic process	IBA
lipid biosynthetic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process

steroid biosynthetic process

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

primary metabolic process [inference]

lipid metabolic process

steroid metabolic process

steroid biosynthetic process

sterol biosynthetic process

sterol metabolic process [inference]

lipid biosynthetic process

steroid biosynthetic process

sterol biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

organic substance metabolic process [inference]

lipid metabolic process

steroid metabolic process

steroid biosynthetic process

sterol biosynthetic process

sterol metabolic process [inference]

lipid biosynthetic process

steroid biosynthetic process

sterol biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process

steroid biosynthetic process

sterol biosynthetic process

sterol metabolic process [inference]

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

sterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process

steroid biosynthetic process

sterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process

sterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IEA
endoplasmic reticulum membrane	IBA
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
C-4 methylsterol oxidase activity	IBA
monooxygenase activity	IEA
iron ion binding	IEA
steroid hydroxylase activity	IBA
oxidoreductase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

monooxygenase activity

steroid hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

C-4 methylsterol oxidase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

C-4 methylsterol oxidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

iron ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cholesterol 25-hydroxylase

Functional Category

C: Energy production and conversion
I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 10** entries
Gene Ontology
C-4 methylsterol oxidase activity
C-5 sterol desaturase activity
cholesterol biosynthetic process via lathosterol
ergosterol biosynthetic process
iron ion binding
lipid biosynthetic process
oxidoreductase activity
sphingolipid biosynthetic process
sphingolipid delta-4 desaturase activity
sphingosine hydroxylase activity

Displaying 1 entry
InterPro
Fatty acid hydroxylase

Ortholog

Displaying entries **1 - 10** of 15 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	9023	SGD:S000002705
Saccharomyces cerevisiae S288C	12642	SGD:S000002705
Saccharomyces cerevisiae S288C	185268	SGD:S000002705
Saccharomyces cerevisiae S288C	309527	SGD:S000002705
Saccharomyces cerevisiae S288C	336673	SGD:S000002705
Saccharomyces cerevisiae S288C	798384	SGD:S000002705
Saccharomyces cerevisiae S288C	100136851	SGD:S000002705
Oryzias latipes	101156734		ORYLA14953
Astyanax mexicanus	103046335		ASTMX21246
Sinocyclocheilus grahami	107567893		SINGR93457

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025