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protein O-fucosyltransferase 2

Summary

Gene Symbol

Pofut2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

80294

KEGG Gene ID

mmu:80294

PubChem

80294

Alliance of Genome Resources

MGI:1916863

Annotation

Keyword

Disulfide bond
Endoplasmic reticulum
Fucose metabolism
Glycoprotein
Glycosyltransferase
Golgi apparatus
Reference proteome
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B2RV73	Peptide-O-fucosyltransferase 2
Q8VHI3	Peptide-O-fucosyltransferase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
mesoderm formation	IMP	20637190
fucose metabolic process	IEA
regulation of gene expression	IMP	20637190
regulation of epithelial to mesenchymal transition	IMP	20637190
fucosylation	IMP	20637190

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

small molecule metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

glycosylation [inference]

fucosylation

protein O-linked fucosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

monosaccharide metabolic process [inference]

hexose metabolic process [inference]

fucose metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation [inference]

protein O-linked fucosylation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

formation of primary germ layer [inference]

mesoderm formation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of protein folding

regulation of developmental process [inference]

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of cell differentiation [inference]

regulation of epithelial to mesenchymal transition

positive regulation of cellular process [inference]

positive regulation of protein folding

regulation of protein folding [inference]

positive regulation of protein folding

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum
endoplasmic reticulum membrane	IMP	20637190
Golgi apparatus	ISO
Golgi apparatus	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
fucosyltransferase activity	IDA	20637190
peptide-O-fucosyltransferase activity	ISS
peptide-O-fucosyltransferase activity	ISO
peptide-O-fucosyltransferase activity	IDA	20637190 33909046
peptide-O-fucosyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

fucosyltransferase activity

peptide-O-fucosyltransferase activity

catalytic activity, acting on a protein [inference]

peptide-O-fucosyltransferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
fucose metabolic process
peptide-O-fucosyltransferase activity
protein O-linked fucosylation
transferase activity

Displaying **all 2** entries
InterPro
GDP-fucose protein O-fucosyltransferase 2-like
GDP-fucose protein O-fucosyltransferase

KEGG BRITE Database

Orthology

K03691

Name

peptide-O-fucosyltransferase [EC:2.4.1.221]

References

11524432

Rhea

RHEA:63644

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

RHEA:70491

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

RHEA:70535

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

RHEA:70539

GDP-β-L-fucose

H⁺ + GDP

Enzyme

2.4.1.221

PMID

Ortholog

Displaying entries **1 - 10** of 64 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	23275	Xenbase:XB-GENE-1018927	HUMAN58956
Xenopus tropicalis	31098	Xenbase:XB-GENE-1018927
Xenopus tropicalis	80294	Xenbase:XB-GENE-1018927
Xenopus tropicalis	259529	Xenbase:XB-GENE-1018927
Rattus norvegicus	309686	Xenbase:XB-GENE-1018927	RATNO21454
Bos taurus	404083		BOVIN15513
Ciona intestinalis	445727		CIOIN00351
Takifugu rubripes	445894		TAKRU26045
Macaca mulatta	721991		MACMU30683
Danio rerio	777668	Xenbase:XB-GENE-1018927	DANRE45274

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Annotation

OrthoDB (Group)

KEGG BRITE Database

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Acknowledgements