GlyCosmos Portal

Submissions

gigaxonin

Summary

Gene Symbol

GAN

Organism

Homo sapiens (human)

External Links

NCBI Gene

8139

KEGG Gene ID

PubChem

8139

Alliance of Genome Resources

HGNC:4137

Annotation

Keyword

3D-structure
Cytoskeleton
Disease variant
Kelch repeat
Neurodegeneration
Neuropathy
Proteomics identification
Reference proteome
Repeat
Ubl conjugation
Ubl conjugation pathway

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A0S2Z4W2
B3KTC3
Q9H2C0	Kelch-like protein 16

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoskeleton organization	IEA
protein ubiquitination	IDA
protein ubiquitination	IEA
proteasome-mediated ubiquitin-dependent protein catabolic process	NAS
proteasome-mediated ubiquitin-dependent protein catabolic process	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

Displaying entries **6 - 9** of 9 in total

« First

‹ Prev

1

2
GO Term	Evidence Code	PMID
microtubule cytoskeleton	IDA
Cul3-RING ubiquitin ligase complex	NAS
Cul3-RING ubiquitin ligase complex	IDA
Cul3-RING ubiquitin ligase complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

ubiquitin ligase complex [inference]

cullin-RING ubiquitin ligase complex [inference]

Cul3-RING ubiquitin ligase complex

catalytic complex [inference]

transferase complex [inference]

ubiquitin ligase complex [inference]

cullin-RING ubiquitin ligase complex [inference]

Cul3-RING ubiquitin ligase complex

cellular anatomical structure [inference]

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton

microtubule cytoskeleton

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI
ubiquitin-like ligase-substrate adaptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

enzyme-substrate adaptor activity [inference]

ubiquitin-like ligase-substrate adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0090068	giant axonal neuropathy 1	Alliance of Genome Resources

About Release Notes Help Feedback

Logo License Policies Site Map

Contact: [email protected]

GlyCosmos Portal v4.5.0

Last updated: April 6, 2026

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements