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Guidelines

MIRAGE

sortilin-related VPS10 domain containing receptor 2

Summary

Gene Symbol

Sorcs2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

81840

PubChem

81840

Alliance of Genome Resources

MGI:1932289

Annotation

Keyword

3D-structure
Cell membrane
Cell projection
Cytoplasmic vesicle
Disulfide bond
Endosome
Glycoprotein
Membrane
Postsynaptic cell membrane
Proteomics identification
Reference proteome
Repeat
Signal
Synaptosome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q8BI61
Q8BI74
Q9EPR5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
intracellular protein transport	IMP	30840898
long-term synaptic depression	IMP	27457814

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport

organic substance transport [inference]

protein transport [inference]

intracellular protein transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic depression

negative regulation of synaptic transmission [inference]

long-term synaptic depression

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of cellular process [inference]

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic plasticity [inference]

long-term synaptic depression

negative regulation of synaptic transmission [inference]

long-term synaptic depression

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of synaptic transmission [inference]

long-term synaptic depression

regulation of biological quality [inference]

regulation of synaptic plasticity [inference]

long-term synaptic depression

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cytosol	ISO
cytosol	IEA
plasma membrane	IDA	30840898
postsynaptic density	IDA	27457814
membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

bounding membrane of organelle [inference]

endosome membrane [inference]

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

postsynaptic specialization [inference]

postsynaptic density

postsynapse [inference]

dendritic spine

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	24908487 30840898

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

VPS10

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
Golgi to vacuole transport
protein targeting to vacuole

Displaying **all 4** entries
InterPro
Sortilin, C-terminal
Sortilin, N-terminal
VPS10
WD40/YVTN repeat-like-containing domain superfamily

Ortholog

Displaying entries **1 - 10** of 63 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	6653	SGD:S000000696
Saccharomyces cerevisiae S288C	22986	SGD:S000000696
Homo sapiens	57537	Xenbase:XB-GENE-956152	HUMAN74824
Saccharomyces cerevisiae S288C	58178	SGD:S000000696
Saccharomyces cerevisiae S288C	66673	SGD:S000000696
Xenopus tropicalis	81840	Xenbase:XB-GENE-956152
Saccharomyces cerevisiae S288C	83576	SGD:S000000696
Saccharomyces cerevisiae S288C	114815	SGD:S000000696
Saccharomyces cerevisiae S288C	294043	SGD:S000000696
Rattus norvegicus	305438		RATNO08483

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025