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MIRAGE
triggering receptor expressed on myeloid cells 2
Summary
- Gene Symbol
-
- Trem2
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- Alternative splicing
- Cell membrane
- Disulfide bond
- Glycoprotein
- Immunoglobulin domain
- Lipid-binding
- Receptor
- Reference proteome
- Secreted
- Signal
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| Q99NH8 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| microglial cell activation | ||
| microglial cell activation | ||
| positive regulation of protein phosphorylation |
|
|
| microglial cell activation involved in immune response | ||
| T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell |
GO Hierarchy
biological process
immune system process [inference]
cellular process [inference]
multicellular organismal process [inference]
response to stimulus [inference]
response to external stimulus [inference]
response to biotic stimulus [inference]
response to chemical [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of antigen processing and presentation [inference]
positive regulation of immune system process [inference]
regulation of immune effector process [inference]
regulation of immune response [inference]
regulation of adaptive immune response [inference]
regulation of humoral immune response [inference]
regulation of innate immune response
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
negative regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of small molecule metabolic process [inference]
regulation of primary metabolic process [inference]
regulation of signaling [inference]
regulation of signal transduction [inference]
regulation of cytokine-mediated signaling pathway [inference]
positive regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of intracellular signal transduction
positive regulation of signaling [inference]
negative regulation of signaling [inference]
regulation of localization [inference]
regulation of transport [inference]
regulation of transmembrane transport [inference]
regulation of monoatomic ion transport [inference]
positive regulation of transport [inference]
regulation of cellular localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of metabolic process [inference]
positive regulation of signaling [inference]
positive regulation of cellular process [inference]
positive regulation of response to stimulus [inference]
positive regulation of transport [inference]
negative regulation of biological process [inference]
negative regulation of metabolic process [inference]
negative regulation of signaling [inference]
negative regulation of cellular process [inference]
negative regulation of response to stimulus [inference]
regulation of response to stimulus [inference]
regulation of response to biotic stimulus [inference]
regulation of signal transduction [inference]
regulation of cytokine-mediated signaling pathway [inference]
positive regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of intracellular signal transduction
regulation of response to external stimulus [inference]
positive regulation of response to stimulus [inference]
negative regulation of response to stimulus [inference]
regulation of immune response [inference]
regulation of adaptive immune response [inference]
regulation of humoral immune response [inference]
regulation of innate immune response
regulation of response to cytokine stimulus [inference]
regulation of response to stress [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of signal transduction [inference]
regulation of cytokine-mediated signaling pathway [inference]
positive regulation of signal transduction [inference]
negative regulation of signal transduction [inference]
regulation of pattern recognition receptor signaling pathway [inference]
regulation of intracellular signal transduction
positive regulation of cell communication [inference]
negative regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
negative regulation of cellular metabolic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of phosphorus metabolic process [inference]
regulation of transmembrane transport [inference]
regulation of programmed cell death [inference]
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
regulation of cellular component organization [inference]
regulation of cellular localization [inference]
regulation of multicellular organismal process [inference]
regulation of cytokine production [inference]
regulation of lipoprotein particle clearance [inference]
positive regulation of multicellular organismal process [inference]
negative regulation of multicellular organismal process [inference]
regulation of molecular function [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular region | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| lipopolysaccharide binding | ||
| amyloid-beta binding | ||
| amyloid-beta binding | ||
| phosphatidylserine binding | ||
| phosphatidylserine binding |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- triggering receptor expressed on myeloid cells 2
- Functional Category
-
- G: Carbohydrate transport and metabolism
- M: Cell wall/membrane/envelope biogenesis
- O: Posttranslational modification, protein turnover, chaperones
| InterPro |
|---|
| Immunoglobulin V-set domain |
| Immunoglobulin subtype |
| Immunoglobulin-like domain superfamily |
| Immunoglobulin-like fold |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:9255 | frontotemporal dementia |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 101024063 | PAPAN34076 | ||
| 101043496 | SAIBB05444 | ||
| 101099297 | FELCA11381 | ||
| 101105447 | SHEEP10250 | ||
| 101672558 | MUSPF18725 | ||
| 101717064 | HETGA01889 | ||
| 102009649 | CHILA10260 | ||
| 102189077 | CAPHI15726 | ||
| 102437564 | MYOLU16419 | ||
| 103221524 | CHLSB06331 |
