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ribonuclease A family member 7

Summary

Gene Symbol

RNASE7

Organism

Homo sapiens (human)

External Links

NCBI Gene

84659

PubChem

84659

Alliance of Genome Resources

HGNC:19278

Annotation

Keyword

3D-structure
Antibiotic
Direct protein sequencing
Disulfide bond
Endonuclease
Glycoprotein
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9H1E1	Skin-derived antimicrobial protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
antibacterial humoral response	IDA	25075772
innate immune response	NAS	12244054
innate immune response	IDA	16940129 25075772
innate immune response	IBA
defense response to Gram-negative bacterium	IDA	12244054 16940129 20180804 25075772

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

innate immune response

cellular process [inference]

cell killing [inference]

killing of cells of another organism [inference]

cytolysis in another organism

cytolysis [inference]

cytolysis in another organism

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

response to fungus [inference]

defense response to fungus

defense response to other organism [inference]

antimicrobial humoral response [inference]

defense response to bacterium [inference]

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism [inference]

cytolysis in another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

antimicrobial humoral response [inference]

defense response to bacterium [inference]

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

response to fungus [inference]

defense response to fungus

defense response to other organism [inference]

antimicrobial humoral response [inference]

defense response to bacterium [inference]

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

response to fungus [inference]

defense response to fungus

defense response to other organism [inference]

antimicrobial humoral response [inference]

defense response to bacterium [inference]

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GO Term	Evidence Code	PMID
extracellular region	NAS	12244054
extracellular region	TAS
extracellular region	IDA	19641608 23302724
extracellular space	IDA	25075772
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

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GO Term	Evidence Code	PMID
lipopolysaccharide binding	IDA	20180804
nucleic acid binding	IEA
endonuclease activity	IEA
RNA nuclease activity	IDA	12244054 19641608
RNA nuclease activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA nuclease activity

binding [inference]

protein binding

lipid binding [inference]

lipopolysaccharide binding

organic cyclic compound binding [inference]

nucleic acid binding

carbohydrate derivative binding [inference]

lipopolysaccharide binding

glycosaminoglycan binding [inference]

peptidoglycan binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ribonuclease 7

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
RNA nuclease activity
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
endonuclease activity
hydrolase activity
nuclease activity

Displaying **all 4** entries
InterPro
Pancreatic ribonuclease
Ribonuclease A, active site
Ribonuclease A-domain
Ribonuclease A-like domain superfamily

Ortholog

Displaying entries **1 - 10** of 34 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	6035	Xenbase:XB-GENE-5802830
Xenopus tropicalis	6039	Xenbase:XB-GENE-5802830
Xenopus tropicalis	19752	Xenbase:XB-GENE-5802830
Xenopus tropicalis	78416	Xenbase:XB-GENE-5802830
Xenopus tropicalis	84659	Xenbase:XB-GENE-5802830
Xenopus tropicalis	364302	Xenbase:XB-GENE-5802830
Macaca mulatta	705600		MACMU40667
Bos taurus	783267		BOVIN00847
Equus caballus	100072707		HORSE15061
Oryctolagus cuniculus	100352281		RABIT06298