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O-linked N-acetylglucosamine (GlcNAc) transferase
Summary
- Gene Symbol
-
- OGT
- Aliases
-
- FLJ23071
- HRNT1
- MGC22921
- O-GLCNAC
- OGT1
- UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Apoptosis
- Biological rhythms
- Cell membrane
- Cell projection
- Chromatin regulator
- Cytoplasm
- Direct protein sequencing
- Disease variant
- Glycoprotein
- Glycosyltransferase
- Host-virus interaction
- Intellectual disability
- Lipid-binding
- Mitochondrion
- Nucleus
- Phosphoprotein
- Reference proteome
- Repeat
- TPR repeat
- Ubl conjugation
- Ubl conjugation pathway
- Proteins
| UniProt | Protein Name |
|---|---|
| O15294 |
|
Gene Ontology (GO)
GO Hierarchy
- positive regulation of cold-induced thermogenesis
- positive regulation of cold-induced thermogenesis
- signal transduction
biological process
metabolic process [inference]
cellular process [inference]
response to stimulus [inference]
response to external stimulus [inference]
response to chemical [inference]
cellular response to stimulus [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
regulation of biosynthetic process [inference]
positive regulation of biosynthetic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
negative regulation of metabolic process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of catabolic process [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of nucleobase-containing compound metabolic process [inference]
regulation of RNA metabolic process [inference]
positive regulation of RNA metabolic process [inference]
regulation of RNA biosynthetic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
regulation of nitrogen compound metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of nucleobase-containing compound metabolic process [inference]
regulation of RNA metabolic process [inference]
positive regulation of RNA metabolic process [inference]
regulation of RNA biosynthetic process [inference]
negative regulation of nitrogen compound metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of macromolecule metabolic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
negative regulation of macromolecule metabolic process [inference]
regulation of protein metabolic process [inference]
regulation of RNA metabolic process [inference]
positive regulation of RNA metabolic process [inference]
regulation of RNA biosynthetic process [inference]
regulation of primary metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of nucleobase-containing compound metabolic process [inference]
regulation of RNA metabolic process [inference]
positive regulation of RNA metabolic process [inference]
regulation of RNA biosynthetic process [inference]
regulation of protein metabolic process [inference]
regulation of signaling [inference]
regulation of localization [inference]
positive regulation of biological process [inference]
positive regulation of metabolic process [inference]
positive regulation of biosynthetic process [inference]
positive regulation of macromolecule metabolic process [inference]
positive regulation of cellular metabolic process [inference]
positive regulation of nitrogen compound metabolic process [inference]
positive regulation of cellular process [inference]
negative regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cellular metabolic process [inference]
regulation of nucleobase-containing compound metabolic process [inference]
positive regulation of nucleobase-containing compound metabolic process [inference]
regulation of RNA metabolic process [inference]
positive regulation of RNA metabolic process [inference]
regulation of RNA biosynthetic process [inference]
positive regulation of cellular metabolic process [inference]
regulation of cellular biosynthetic process [inference]
regulation of macromolecule biosynthetic process [inference]
regulation of gene expression [inference]
positive regulation of macromolecule biosynthetic process [inference]
regulation of RNA biosynthetic process [inference]
positive regulation of cellular process [inference]
negative regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleus | ||
| glutamatergic synapse | ||
| protein-containing complex | ||
| Sin3-type complex | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| acetylglucosaminyltransferase activity | ||
| protein O-acetylglucosaminyltransferase activity | ||
| phosphatidylinositol-3,4,5-trisphosphate binding | ||
| protein binding | ||
| chromatin DNA binding |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
GlycoGene Database (GGDB)
- GGDB ID
- gg114
- Gene Symbol
-
- OGT
- Orthologous Gene
| Species | Protein | mRNA |
|---|---|---|
| Mus musculus | NP_631883 | NM_139144 |
| Rattus norvegicus | NP_058803 | NM_017107 |
| Drosophila melanogaster | NP_724406 | NM_165426 |
| Caenorhabditis elegans | NP_498563 | NM_066162 |
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0080240 | non-syndromic X-linked intellectual disability 106 | |
| DOID:1712 | aortic valve stenosis | |
| DOID:6000 | congestive heart failure | |
| DOID:9351 | diabetes mellitus | |
| DOID:9352 | type 2 diabetes mellitus |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001249 | Intellectual disability |
| HP:0001263 | Global developmental delay |
| HP:0001419 | X-linked recessive inheritance |
| HP:0001647 | Bicuspid aortic valve |
| HP:0002236 | Frontal upsweep of hair |
| HP:0004209 | Clinodactyly of the 5th finger |
| HP:0008499 | High hypermetropia |
| HP:0008734 | Decreased testicular size |
| HP:0012471 | Thick vermilion border |
| Disease ID | Disease Name |
|---|---|
| OMIM:300997 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP001229
- Gene Name
- O-linked N-acetylglucosamine (GlcNAc) transferase
ChIP-Atlas
- Target Genes
-
Predicted target genes bound by given transcription factors. Target Genes
Potential target genes for OGT
Distance from TSS: ± 10 kb
| Gene Symbol | Description | Cellline (score) |
|---|---|---|
| dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 |
|
|
| SAC1 like phosphatidylinositide phosphatase |
|
|
| atlastin GTPase 3 |
|
|
| glucosidase II alpha subunit |
|
|
| RAB11A, member RAS oncogene family |
|
|
| dolichol kinase |
|
|
| decapping mRNA 1A |
|
|
| O-linked N-acetylglucosamine (GlcNAc) transferase |
|
- Colocalization
-
Predicted partner proteins colocalizing with given transcription factors. Colocalization
Colocalization analysis for OGT
| Gene Symbol | Description | Cellline (score) |
|---|---|---|
| O-linked N-acetylglucosamine (GlcNAc) transferase |
|
