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PTPRF interacting protein alpha 2

Summary

Gene Symbol

PPFIA2

Organism

Homo sapiens (human)

External Links

NCBI Gene

8499

PubChem

8499

Alliance of Genome Resources

HGNC:9246

Annotation

Keyword

3D-structure
Alternative splicing
Cell projection
Coiled coil
Cytoplasm
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Synapse

Proteins

Displaying **all 5** entries
UniProt	Protein Name
B7Z7Y5
Q4LE62
H0YHK3
O75334	Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2
G3V200

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
cell-matrix adhesion	TAS	9624153
synapse organization	IBA
regulation of dendritic spine development	IMP	30021165
regulation of dendritic spine morphogenesis	IMP	30021165
presynapse organization	IEA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

cellular localization [inference]

intracellular transport [inference]

cytosolic transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport

cytoskeleton-dependent intracellular transport [inference]

vesicle cytoskeletal trafficking [inference]

dense core granule cytoskeletal transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

postsynaptic specialization organization [inference]

postsynaptic density organization [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

cell junction organization [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

synapse organization

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

cellular component maintenance [inference]

cell junction maintenance [inference]

maintenance of synapse structure [inference]

maintenance of postsynaptic specialization structure [inference]

maintenance of postsynaptic density structure

presynapse organization

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

cytosolic transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport

cytoskeleton-dependent intracellular transport [inference]

vesicle cytoskeletal trafficking [inference]

dense core granule cytoskeletal transport

establishment of localization in cell [inference]

intracellular transport [inference]

cytosolic transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport

cytoskeleton-dependent intracellular transport [inference]

vesicle cytoskeletal trafficking [inference]

dense core granule cytoskeletal transport

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

dense core granule cytoskeletal transport

dense core granule transport [inference]

dense core granule cytoskeletal transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

dense core granule cytoskeletal transport

dense core granule transport [inference]

dense core granule cytoskeletal transport

organelle localization [inference]

vesicle localization [inference]

secretory granule localization [inference]

dense core granule localization [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

dense core granule cytoskeletal transport

dense core granule transport [inference]

dense core granule cytoskeletal transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

dense core granule cytoskeletal transport

dense core granule transport [inference]

dense core granule cytoskeletal transport

cellular localization [inference]

intracellular transport [inference]

cytosolic transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport

cytoskeleton-dependent intracellular transport [inference]

vesicle cytoskeletal trafficking [inference]

dense core granule cytoskeletal transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of dendritic spine morphogenesis

regulation of dendritic spine development

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of dendritic spine morphogenesis

regulation of synapse organization [inference]

regulation of postsynapse organization [inference]

regulation of dendritic spine morphogenesis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
cytoplasm	TAS	9624153
cytosol	TAS
synaptic vesicle	IEA
cell surface	IEA
postsynaptic density	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

postsynaptic specialization [inference]

postsynaptic density

presynaptic active zone

postsynapse [inference]

dendritic spine

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	12923177 30021165
structural constituent of postsynaptic density	IEA
structural constituent of presynapse	IEA

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of synapse [inference]

structural constituent of presynapse

structural constituent of postsynapse [inference]

structural constituent of postsynaptic specialization [inference]

structural constituent of postsynaptic density

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

liprin-alpha

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
synapse organization

Displaying **all 6** entries
InterPro
LAR-interacting protein, Liprin
Liprin-alpha, SAM domain repeat 1
Liprin-alpha, SAM domain repeat 2
Liprin-alpha, SAM domain repeat 3
Sterile alpha motif domain
Sterile alpha motif/pointed domain superfamily

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	8497	FB:FBgn0046704
Danio rerio	8499	ZFIN:ZDB-GENE-030131-7905
Drosophila melanogaster	8500	FB:FBgn0046704
Drosophila melanogaster	8541	FB:FBgn0046704
Drosophila melanogaster	76787	FB:FBgn0046704
Mus musculus	327814	ZFIN:ZDB-GENE-030131-7905	MOUSE01290
Rattus norvegicus	362876		RATNO37076
Pan troglodytes	452101		PANTR06508
Canis lupus familiaris	475415		CANLF04197
Bos taurus	536906		BOVIN28914