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Liprin-alpha-2

Summary

UniProt ID: O75334
Gene Symbol: PPFIA2
Gene ID: 8499
Organism: Homo sapiens (human)

External Links

GlyGen: O75334
The O-GlcNAc Database: O75334
Re-Glyco: O75334

Annotation

Keyword: 3D-structure Alternative splicing Cell projection Coiled coil Cytoplasm Phosphoprotein Proteomics identification Reference proteome Repeat Synapse

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
cell-matrix adhesion	TAS	PMID
synapse organization	IBA	GO_REF
regulation of dendritic spine development	IMP	PMID
regulation of dendritic spine morphogenesis	IMP	PMID
dense core granule cytoskeletal transport	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

cellular localization [inference]

intracellular transport [inference]

cytosolic transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport

cytoskeleton-dependent intracellular transport [inference]

vesicle cytoskeletal trafficking [inference]

dense core granule cytoskeletal transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

cytosolic transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport

cytoskeleton-dependent intracellular transport [inference]

vesicle cytoskeletal trafficking [inference]

dense core granule cytoskeletal transport

establishment of localization in cell [inference]

intracellular transport [inference]

cytosolic transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport

cytoskeleton-dependent intracellular transport [inference]

vesicle cytoskeletal trafficking [inference]

dense core granule cytoskeletal transport

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

dense core granule cytoskeletal transport

dense core granule transport [inference]

dense core granule cytoskeletal transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

dense core granule cytoskeletal transport

dense core granule transport [inference]

dense core granule cytoskeletal transport

organelle localization [inference]

vesicle localization [inference]

secretory granule localization [inference]

dense core granule localization [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

dense core granule cytoskeletal transport

dense core granule transport [inference]

dense core granule cytoskeletal transport

establishment of organelle localization [inference]

establishment of vesicle localization [inference]

vesicle cytoskeletal trafficking [inference]

dense core granule cytoskeletal transport

dense core granule transport [inference]

dense core granule cytoskeletal transport

cellular localization [inference]

intracellular transport [inference]

cytosolic transport [inference]

dense core granule transport [inference]

dense core granule cytoskeletal transport

cytoskeleton-dependent intracellular transport [inference]

vesicle cytoskeletal trafficking [inference]

dense core granule cytoskeletal transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of dendritic spine morphogenesis

regulation of dendritic spine development

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of dendritic spine morphogenesis

regulation of synapse organization [inference]

regulation of postsynapse organization [inference]

regulation of dendritic spine morphogenesis

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

regulation of regulated secretory pathway [inference]

regulation of synaptic vesicle exocytosis

regulation of neurotransmitter secretion [inference]

regulation of synaptic vesicle exocytosis

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
cytoplasm	TAS	PMID
cytoplasm	IEA	GO_REF GO_REF
cytosol	TAS	Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome
synaptic vesicle	IEA	GO_REF
cell surface	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

postsynaptic specialization [inference]

postsynaptic density

presynaptic active zone

postsynapse [inference]

dendritic spine

Displaying **all 2** entries
GO Term	Evidence Code	Reference
structural constituent of postsynaptic density	IEA	GO_REF
structural constituent of presynapse	IEA	GO_REF

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of synapse [inference]

structural constituent of presynapse

structural constituent of postsynapse [inference]

structural constituent of postsynaptic specialization [inference]

structural constituent of postsynaptic density

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MMCEVMPTINEDTPMSQRGSQSSGSDSDSHFEQLMVNMLDERDRLLDTLRETQESLSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMRTGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTASSLASSSPPSGHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDGREDKATIKCETSPPPTPRALRMTHTLPSSYHNDARSSLSVSLEPESLGLGSANSSQDSLHKAPKKKGIKSSIGRLFGKKEKARLGQLRGFMETEAAAQESLGLGKLGTQAEKDRRLKKKHELLEEARRKGLPFAQWDGPTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPPTSRTPSGNVWVTHEEMENLAAPAKTKESEEGSWAQCPVFLQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELERRREASQHEIKDVLVWSNDRVIRWIQAIGLREYANNILESGVHGSLIALDENFDYSSLALLLQIPTQNTQARQILEREYNNLLALGTERRLDESDDKNFRRGSTWRRQFPPREVHGISMMPGSSETLPAGFRLTTTSGQSRKMTTDVASSRLQRLDNSTVRTYSC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
315		29237092 30379171	G49108TO	The O-GlcNAc Database
778				GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Acetylcholine Neurotransmitter Release Cycle	Homo sapiens
Dopamine Neurotransmitter Release Cycle	Homo sapiens
Glutamate Neurotransmitter Release Cycle	Homo sapiens
Norepinephrine Neurotransmitter Release Cycle	Homo sapiens
Receptor-type tyrosine-protein phosphatases	Homo sapiens
Serotonin Neurotransmitter Release Cycle	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements