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Serotonin Neurotransmitter Release Cycle

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-181429

PubChem

R-HSA-181429

Description

Serotonin is synthesized in the serotonergic neurons in the central nervous system and the enterochrommaffin cells of the gastroinetstinal system. Serotonin is loaded into the clathrin sculpted monoamine transport vesicles. The vesicles are docked, primed and release after the change in the membrane potential that activates voltage gated calcium channels and the reponse by several proetins to the changes in intracellular Ca2+ increase leads to fusion of the vesicle and release of serotonin into the synapse.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 13 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O14795	Protein unc-13 homolog B	UNC13 UNC13B	view
O14994	Synapsin-3	SYN3	view
O75145	Liprin-alpha-3	KIAA0654 PPFIA3	view
O75334	Liprin-alpha-2	PPFIA2	view
O75335	Liprin-alpha-4	KIAA0897 PPFIA4	view
P17600	Synapsin-1	SYN1	view
P21579	Synaptotagmin-1	SVP65 SYT SYT1	view
P60880	Synaptosomal-associated protein 25	SNAP SNAP25	view
Q05940	Synaptic vesicular amine transporter	SLC18A2 SVMT VMAT2	view
Q13136	Liprin-alpha-1	LIP1 PPFIA1	view

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