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Receptor-type tyrosine-protein phosphatases

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-388844

PubChem

R-HSA-388844

Description

Like neurexins, Receptor-like protein tyrosine phosphatases (RPTPs) make trans-synaptic adhesion complexes with multiple postsynaptic binding partners to regulate synapse organization. The type IIa RPTPs include three members, Receptor-type tyrosine-protein phosphatase F (PTPRF) sometimes referred to as leukocyte common antigen-related (LAR), Receptor-type tyrosine-protein phosphatase sigma (PTPRS) and Receptor-type tyrosine-protein phosphatase delta (PTPRD). These proteins contain typical cell adhesion immunoglobulin-like (Ig) and fibronectin III (FNIII) domains, suggesting the involvement of RPTPs in cell-cell and cell-matrix interactions. To date, six different types of postsynaptic organizers for type-IIa RPTPs have been reported: interleukin-1 receptor accessory protein (IL1RAP, IL-1RAcP) (Yoshida et al. 2012), IL-1RAcP-like-1 (IL1RAPL1) (Yoshida et al. 2011), Neurotrophin receptor tyrosine kinase 3 (NTRK3, TrkC) (Takahashi et al. 2011), Leucine-rich repeat-containing protein 4B (LRRC4B, Netrin-G ligand-3, NGL-3) (Woo et al. 2009, Kwon et al. 2010), the Slit- and Trk-like (Slitrk) family proteins (Takahashi et al. 2012, Yim et al. 2013, Yamagata et al. 2015) and the liprins (Serra-Pagès et al. 1998, Dunah et al. 2005).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 19 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O75145	Liprin-alpha-3	KIAA0654 PPFIA3	view
O75334	Liprin-alpha-2	PPFIA2	view
O75335	Liprin-alpha-4	KIAA0897 PPFIA4	view
O94933	SLIT and NTRK-like protein 3	KIAA0848 SLITRK3	view
O94991	SLIT and NTRK-like protein 5	KIAA0918 LRRC11 SLITRK5	view
P10586	Receptor-type tyrosine-protein phosphatase F	LAR PTPRF	view
P23468	Receptor-type tyrosine-protein phosphatase delta	PTPRD	view
Q13136	Liprin-alpha-1	LIP1 PPFIA1	view
Q13332	Receptor-type tyrosine-protein phosphatase S	PTPRS	view
Q16288	NT-3 growth factor receptor	NTRK3 TRKC	view

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