GlyCosmos Portal

Annotation

Keyword

3D-structure
Endoplasmic reticulum
Glycoprotein
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q05787	HMG-CoA reductase degradation protein 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
retrograde protein transport, ER to cytosol	IMP	24292014
detection of unfolded protein
negative regulation of protein autoubiquitination	IDA	31713515
ERAD pathway	IDA	12105183

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

response to topologically incorrect protein [inference]

response to unfolded protein [inference]

detection of unfolded protein

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

ERAD pathway

response to topologically incorrect protein [inference]

response to unfolded protein [inference]

detection of unfolded protein

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

ERAD pathway

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of unfolded protein

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

regulation of post-translational protein modification [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

regulation of protein autoubiquitination [inference]

negative regulation of protein autoubiquitination

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

regulation of post-translational protein modification [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

regulation of protein autoubiquitination [inference]

negative regulation of protein autoubiquitination

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

regulation of post-translational protein modification [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein ubiquitination [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

regulation of protein autoubiquitination [inference]

negative regulation of protein autoubiquitination

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein modification process [inference]

negative regulation of post-translational protein modification [inference]

negative regulation of protein modification by small protein conjugation or removal [inference]

negative regulation of protein ubiquitination [inference]

negative regulation of protein autoubiquitination

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
endoplasmic reticulum	HDA IEA	26928762
Hrd1p ubiquitin ligase ERAD-M complex	IDA	16873066

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

ER ubiquitin ligase complex [inference]

Hrd1p ubiquitin ligase complex

endoplasmic reticulum protein-containing complex [inference]

ER ubiquitin ligase complex [inference]

Hrd1p ubiquitin ligase complex

luminal surveillance complex

intracellular protein-containing complex [inference]

ubiquitin ligase complex [inference]

cytoplasmic ubiquitin ligase complex [inference]

ER ubiquitin ligase complex [inference]

Hrd1p ubiquitin ligase complex

catalytic complex [inference]

transferase complex [inference]

ubiquitin ligase complex [inference]

cytoplasmic ubiquitin ligase complex [inference]

ER ubiquitin ligase complex [inference]

Hrd1p ubiquitin ligase complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying 1 entry
GO Term	Evidence Code	PMID
ubiquitin-protein transferase activity	IDA	11390656

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sel-1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
ERAD pathway

Displaying **all 2** entries
InterPro
Sel1-like repeat
Tetratricopeptide-like helical domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 5** entries
Location	References
Hrd1p ubiquitin ligase ERAD-M complex	PMID:16873066
luminal surveillance complex	PMID:16873065
endoplasmic reticulum	PMID:26928762
endoplasmic reticulum membrane	PMID:16619026
Hrd1p ubiquitin ligase ERAD-L complex	PMID:16873066

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1793	pancreatic cancer	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 35 in total

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Species	Gene ID	OrthoDB
Tetrapisispora phaffii CBS 4417	11535524	1071381_0:000a4a
Kazachstania africana CBS 2517	13886962	1071382_0:001497
Tetrapisispora blattae CBS 6284	14496329	1071380_0:000e65
Eremothecium sinecaudum	28725367	45286_0:000ec6
Saccharomyces eubayanus	28932858	1080349_0:000e36
Kazachstania naganishii CBS 8797	34524359	1071383_0:000376
Lachancea lanzarotensis	34686042	1245769_0:00094f
Kluyveromyces marxianus DMKU3-1042	34718007	1003335_0:001195
Saccharomyces paradoxus	54632332	27291_0:000e43
Zygotorulaspora mrakii	59237164	42260_0:000b98

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements