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phytoceramidase

Summary

Gene Symbol

YPC1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

852481

PubChem

852481

Alliance of Genome Resources

SGD:S000000387

Annotation

Keyword

Disulfide bond
Endoplasmic reticulum
Hydrolase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P38298	Acyl-CoA-independent ceramide synthase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
ceramide metabolic process	IEA
ceramide catabolic process	IBA IMP	10702247
ceramide biosynthetic process	IBA IGI	11694577
sphingolipid metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

amide metabolic process [inference]

ceramide metabolic process

amide biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
membrane	IEA
cortical endoplasmic reticulum	IDA	24866405
endoplasmic reticulum membrane	IBA IEA
endoplasmic reticulum	HDA IDA IEA	10900202 26928762

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle subcompartment [inference]

endoplasmic reticulum subcompartment [inference]

endoplasmic reticulum tubular network [inference]

cortical endoplasmic reticulum

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
phytoceramidase activity
hydrolase activity	IEA
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IEA
sphingosine N-acyltransferase activity	IGI IMP	10702247 11694577
N-acylsphingosine amidohydrolase activity	IBA IMP	10702247 10900202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

N-acyltransferase activity [inference]

sphingosine N-acyltransferase activity

hydrolase activity

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

phytoceramidase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

N-acylsphingosine amidohydrolase activity

phytoceramidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alkaline

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
ceramide biosynthetic process
ceramide catabolic process
ceramide metabolic process
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
hydrolase activity
phytoceramidase activity
sphingolipid metabolic process

Displaying 1 entry
InterPro
Alkaline ceramidase

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
cortical endoplasmic reticulum	PMID:24866405
endoplasmic reticulum	PMID:10900202 PMID:26928762

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080547	metabolic dysfunction-associated steatohepatitis	Alliance of Genome Resources
DOID:10579	leukodystrophy	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP007166
Gene Name: phytoceramidase

Ortholog

Displaying entries **11 - 20** of 38 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Lachancea thermotolerans CBS 6340	8292216	559295_0:000873
Eremothecium cymbalariae DBVPG#7215	11472410	931890_0:000f11
Naumovozyma dairenensis CBS 421	11496573	1071378_0:000670
Naumovozyma dairenensis CBS 421	11498666	1071378_0:000bf9
Torulaspora delbrueckii	11503386	4950_0:0001a5
Naumovozyma castellii CBS 4309	11526310	1064592_0:0006d8
Naumovozyma castellii CBS 4309	11528012	1064592_0:000b1b
Tetrapisispora phaffii CBS 4417	11531731	1071381_0:001113
Tetrapisispora phaffii CBS 4417	11534663	1071381_0:000e04
Kazachstania africana CBS 2517	13882735	1071382_0:000abb

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024