GlyCosmos Portal

Submissions

phytoceramidase

Summary

Gene Symbol

YPC1

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

852481

PubChem

852481

Alliance of Genome Resources

SGD:S000000387

Annotation

Keyword

Disulfide bond
Endoplasmic reticulum
Hydrolase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P38298	Acyl-CoA-independent ceramide synthase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
ceramide biosynthetic process	IBA IGI	11694577
ceramide catabolic process	IBA IMP	10702247
sphingolipid metabolic process	IEA
ceramide metabolic process	IEA
phytosphingosine biosynthetic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

phytosphingosine biosynthetic process

amide metabolic process [inference]

ceramide metabolic process

amide biosynthetic process [inference]

ceramide biosynthetic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

phytosphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

phytosphingosine biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

phytosphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organonitrogen compound catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

organonitrogen compound biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

organic hydroxy compound biosynthetic process [inference]

alcohol biosynthetic process [inference]

polyol biosynthetic process [inference]

phytosphingosine biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

phytosphingosine biosynthetic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

ceramide biosynthetic process

phytosphingosine biosynthetic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process

ceramide metabolic process

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

sphingolipid catabolic process [inference]

ceramide catabolic process

sphingoid metabolic process [inference]

phytosphingosine metabolic process [inference]

phytosphingosine biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

membrane lipid biosynthetic process [inference]

sphingolipid biosynthetic process [inference]

ceramide biosynthetic process

sphingoid biosynthetic process [inference]

phytosphingosine biosynthetic process

cellular lipid catabolic process [inference]

membrane lipid catabolic process [inference]

sphingolipid catabolic process [inference]

ceramide catabolic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	HDA IDA IEA	10900202 26928762
endoplasmic reticulum membrane	IBA IEA
cortical endoplasmic reticulum	IDA	24866405
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle subcompartment [inference]

endoplasmic reticulum subcompartment [inference]

endoplasmic reticulum tubular network [inference]

cortical endoplasmic reticulum

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 4** entries
GO Term	Evidence Code	PMID
phytoceramidase activity	IBA IMP	10702247 10900202
sphingosine N-acyltransferase activity	IGI IMP	10702247 11694577
hydrolase activity	IEA
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

N-acyltransferase activity [inference]

sphingosine N-acyltransferase activity

hydrolase activity

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

phytoceramidase activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

N-acylsphingosine amidohydrolase activity [inference]

phytoceramidase activity

Gene Ontology information from NCBI Gene and UniProt.

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
endoplasmic reticulum	PMID:10900202 PMID:26928762
cortical endoplasmic reticulum	PMID:24866405

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080547	metabolic dysfunction-associated steatohepatitis	Alliance of Genome Resources
DOID:10579	leukodystrophy	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP007166
Gene Name: phytoceramidase

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Drosophila melanogaster	250736	FB:FBgn0045064
Danio rerio	555411	ZFIN:ZDB-GENE-091204-155
Xenopus tropicalis	100127611	Xenbase:XB-GENE-994450
Homo sapiens	55331	HGNC:16066
Mus musculus	66190	MGI:1913440
Rattus norvegicus	499210	RGD:1561254

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements