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Atg12p

Summary

Gene Symbol

ATG12

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

852518

PubChem

852518

Alliance of Genome Resources

SGD:S000000421

Annotation

Keyword

3D-structure
Autophagy
Isopeptide bond
Membrane
Phosphoprotein
Protein transport
Reference proteome
Ubl conjugation pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
P38316	Autophagy-related protein 12

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
autophagy	IEA
autophagy of mitochondrion	IBA IMP	19793921
piecemeal microautophagy of the nucleus	IBA IMP	18701704
protein lipidation involved in autophagosome assembly	IMP	24485455
protein transport	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation

protein lipidation involved in autophagosome assembly

catabolic process [inference]

cellular catabolic process [inference]

autophagy

autophagy of mitochondrion

macroautophagy

nucleophagy

piecemeal microautophagy of the nucleus

glycophagy

microautophagy [inference]

piecemeal microautophagy of the nucleus

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

autophagy of mitochondrion

macroautophagy

nucleophagy

piecemeal microautophagy of the nucleus

glycophagy

microautophagy [inference]

piecemeal microautophagy of the nucleus

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation

protein lipidation involved in autophagosome assembly

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation

protein lipidation involved in autophagosome assembly

macromolecule modification [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation

protein lipidation involved in autophagosome assembly

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

C-terminal protein lipidation

protein lipidation involved in autophagosome assembly

post-translational protein modification [inference]

C-terminal protein amino acid modification [inference]

C-terminal protein lipidation

protein lipidation involved in autophagosome assembly

cellular process [inference]

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

autophagy of mitochondrion

macroautophagy

nucleophagy

piecemeal microautophagy of the nucleus

glycophagy

microautophagy [inference]

piecemeal microautophagy of the nucleus

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

cytoplasm to vacuole transport by the Cvt pathway

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

cytoplasm to vacuole transport by the Cvt pathway

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

cytoplasm to vacuole transport by the Cvt pathway

protein transport

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

cytoplasm to vacuole transport by the Cvt pathway

process utilizing autophagic mechanism [inference]

autophagy

autophagy of mitochondrion

macroautophagy

nucleophagy

piecemeal microautophagy of the nucleus

glycophagy

microautophagy [inference]

piecemeal microautophagy of the nucleus

cytoplasm to vacuole transport by the Cvt pathway

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization [inference]

autophagy of mitochondrion

vacuole organization [inference]

autophagosome organization [inference]

autophagosome assembly

organelle assembly [inference]

autophagosome assembly

organelle disassembly [inference]

autophagy of mitochondrion

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

organelle disassembly [inference]

autophagy of mitochondrion

cellular component assembly [inference]

organelle assembly [inference]

autophagosome assembly

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

cytoplasm to vacuole transport by the Cvt pathway

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

cytoplasm to vacuole transport by the Cvt pathway

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

cytoplasm to vacuole transport by the Cvt pathway

protein transport

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

cytoplasm to vacuole transport by the Cvt pathway

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

cytoplasm to vacuole transport by the Cvt pathway

protein transport

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

cytoplasm to vacuole transport by the Cvt pathway

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

cytoplasm to vacuole transport by the Cvt pathway

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

cytoplasm to vacuole transport by the Cvt pathway

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole [inference]

cytoplasm to vacuole transport by the Cvt pathway

protein transport

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole [inference]

cytoplasm to vacuole transport by the Cvt pathway

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
membrane	IEA
phagophore assembly site membrane	IBA IEA
autophagosome membrane	IBA
Atg12-Atg5-Atg16 complex	IBA IDA	11897782
transferase complex

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex

Atg12-Atg5-Atg16 complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

autophagosome membrane

phagophore assembly site membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein tag activity	IBA IPI	10233150 10508157 9759731
Atg8-family ligase activity	IBA IDA	17986448
enzyme activator activity	IDA	23503366

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-like protein ligase activity [inference]

Atg8-family ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-like protein ligase activity [inference]

Atg8-family ligase activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity

molecular function activator activity [inference]

enzyme activator activity

molecular tag activity [inference]

protein tag activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Ubiquitin-like protein

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
autophagosome assembly
nucleophagy

Displaying **all 2** entries
InterPro
Ubiquitin-like domain superfamily
Ubiquitin-like protein Atg12

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
cytosol	PMID:26928762
Atg12-Atg5-Atg16 complex	PMID:11897782

Ortholog

Displaying entries **1 - 10** of 29 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	9140		HGNC:588
Drosophila melanogaster	39383		FB:FBgn0036255
Mus musculus	67526		MGI:1914776
Caenorhabditis elegans	175793		WB:WBGene00002982
Rattus norvegicus	361321		RGD:1306306
Danio rerio	570965		ZFIN:ZDB-GENE-071205-7
Kluyveromyces lactis	2892360	28985_0:000685
Eremothecium gossypii ATCC 10895	4618739	284811_0:0000b2
Vanderwaltozyma polyspora DSM 70294	5545792	436907_0:000c90
Lachancea thermotolerans CBS 6340	8294484	559295_0:001202