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Guidelines

MIRAGE

translation initiation factor eIF4G

Summary

Gene Symbol

TIF4631

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

853071

PubChem

853071

Alliance of Genome Resources

SGD:S000003394

Annotation

Keyword

3D-structure
Cytoplasm
Initiation factor
Phosphoprotein
RNA-binding
Reference proteome
Translation regulation

Proteins

Displaying 1 entry
UniProt	Protein Name
P39935	Translation initiation factor 4(4)-F(6) subunit gamma(3) protein 1 eIF4G1 mRNA cap-binding protein complex subunit p150

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
translation	IEA
translational initiation	IMP	12810920
translational initiation	IBA
translational initiation	IEA
regulation of translation	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

amide metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular metabolic process [inference]

translational initiation

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

primary metabolic process [inference]

protein metabolic process [inference]

translation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular metabolic process [inference]

translational initiation

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

stress granule assembly

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

stress granule assembly

cellular component biogenesis [inference]

ribonucleoprotein complex biogenesis [inference]

ribosomal large subunit biogenesis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of protein metabolic process

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of protein metabolic process

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of primary metabolic process [inference]

regulation of protein metabolic process

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
P-body	IDA	23222640
P-body	IEA
cytoplasm	IDA	21925384
cytoplasm	IEA
mitochondrion	HDA	14576278 16823961

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

RNA cap binding complex [inference]

eukaryotic translation initiation factor 4F complex

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribosome

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular non-membrane-bounded organelle [inference]

ribosome

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
translation initiation factor activity	IBA
translation initiation factor activity	IEA
protein binding	IPI	21925384
molecular condensate scaffold activity

GO Hierarchy

molecular function

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

mRNA binding

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

molecular condensate scaffold activity

molecular function regulator activity [inference]

ATPase regulator activity [inference]

ATPase activator activity

molecular function activator activity [inference]

ATPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

initiation factor

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
InterPro
Armadillo-type fold
Eukaryotic translation initiation factor 4G1, eIF4E-binding domain
Initiation factor 4G
MIF4G-like, type 3
eIF4G, eIF4e-binding domain superfamily

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
cytoplasm	PMID:21925384
mitochondrion	PMID:14576278 PMID:16823961
cytoplasmic stress granule	PMID:17908917 PMID:18981231 PMID:26777405
P-body	PMID:23222640

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14330	Parkinson's disease	Alliance of Genome Resources

Ortholog

Displaying **all 9** entries
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1981	Xenbase:XB-GENE-986249
Xenopus tropicalis	1982	Xenbase:XB-GENE-996465
Xenopus tropicalis	8672	Xenbase:XB-GENE-1010293
Xenopus tropicalis	13690	Xenbase:XB-GENE-996465
Xenopus tropicalis	43839	Xenbase:XB-GENE-986249
Xenopus tropicalis	208643	Xenbase:XB-GENE-986249
Xenopus tropicalis	230861	Xenbase:XB-GENE-1010293
Xenopus tropicalis	852833	Xenbase:XB-GENE-996465
Xenopus tropicalis	853071	Xenbase:XB-GENE-996465

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Last updated: December 8, 2025