GlyCosmos Portal

Annotation

Keyword

3D-structure
Cytoplasm
Initiation factor
Phosphoprotein
RNA-binding
Reference proteome
Translation regulation

Proteins

Displaying 1 entry
UniProt	Protein Name
P39935	Translation initiation factor 4(4)-F(6) subunit gamma(3) protein 1 eIF4G1 mRNA cap-binding protein complex subunit p150

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
regulation of protein metabolic process
translational initiation	IBA IEA IMP	12810920
translation	IEA
positive regulation of endoplasmic reticulum unfolded protein response
positive regulation of formation of translation preinitiation complex	IDA	30281017

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

amide metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular metabolic process [inference]

translational initiation

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

primary metabolic process [inference]

protein metabolic process [inference]

translation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

translation

protein metabolic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular process [inference]

cell communication [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular metabolic process [inference]

translational initiation

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

translation

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process [inference]

translation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

stress granule assembly

cellular component assembly [inference]

organelle assembly [inference]

non-membrane-bounded organelle assembly [inference]

stress granule assembly

cellular component biogenesis [inference]

ribonucleoprotein complex biogenesis [inference]

ribosomal large subunit biogenesis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to external stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stimulus [inference]

cellular response to extracellular stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of protein metabolic process

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of protein metabolic process

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of primary metabolic process [inference]

regulation of protein metabolic process

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of translational initiation

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cytoplasmic translation [inference]

regulation of cytoplasmic translational initiation [inference]

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

regulation of cellular component biogenesis [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of cellular component biogenesis [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

regulation of cellular component organization [inference]

regulation of protein-containing complex assembly [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

regulation of formation of translation preinitiation complex [inference]

positive regulation of formation of translation preinitiation complex

positive regulation of cellular component organization [inference]

positive regulation of protein-containing complex assembly [inference]

positive regulation of formation of translation preinitiation complex

regulation of cellular response to stress [inference]

regulation of response to endoplasmic reticulum stress [inference]

regulation of endoplasmic reticulum unfolded protein response [inference]

positive regulation of endoplasmic reticulum unfolded protein response

positive regulation of response to endoplasmic reticulum stress [inference]

positive regulation of endoplasmic reticulum unfolded protein response

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cytoplasmic stress granule	HDA IDA IEA	17908917 18981231 26777405
ribosome
P-body	IDA IEA	23222640
mitochondrion	HDA	14576278 16823961
eukaryotic translation initiation factor 4F complex	IBA IMP	8336723

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

RNA cap binding complex [inference]

eukaryotic translation initiation factor 4F complex

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

ribosome

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular non-membrane-bounded organelle [inference]

ribosome

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	21925384
translation initiation factor activity	IBA IEA
mRNA binding	HDA IBA	23222640
ATPase activator activity	IDA	18606994 21062831 24080224
RNA binding	IDA IEA	12810920

GO Hierarchy

molecular function

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

mRNA binding

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

molecular condensate scaffold activity

molecular function regulator activity [inference]

ATPase regulator activity [inference]

ATPase activator activity

molecular function activator activity [inference]

ATPase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

eukaryotic translation initiation factor 4 gamma

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Armadillo-type fold
Initiation factor 4G
MIF4G-like, type 3

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
cytoplasmic stress granule	PMID:17908917 PMID:18981231 PMID:26777405
mitochondrion	PMID:14576278 PMID:16823961
P-body	PMID:23222640
cytoplasm	PMID:21925384

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0060892	late onset Parkinson's disease	Alliance of Genome Resources
DOID:10763	hypertension	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:1591	renovascular hypertension	Alliance of Genome Resources

Ortholog

Displaying entries **11 - 20** of 49 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Danio rerio	323453		ZFIN:ZDB-GENE-030131-2173
Danio rerio	334618		ZFIN:ZDB-GENE-030131-6550
Rattus norvegicus	361628		RGD:1305294
Xenopus tropicalis	448460		Xenbase:XB-GENE-996465
Danio rerio	566131		ZFIN:ZDB-GENE-120810-2
Danio rerio	568761		ZFIN:ZDB-GENE-090312-49
Danio rerio	572435		ZFIN:ZDB-GENE-070112-702
Kluyveromyces lactis	2896573	28985_0:0001bf
Eremothecium gossypii ATCC 10895	4622921	284811_0:0010d9
Vanderwaltozyma polyspora DSM 70294	5544296	436907_0:000750

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements