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cohesin subunit SMC3

Summary

Gene Symbol

SMC3

Organism

Saccharomyces cerevisiae S288C

External Links

NCBI Gene

853371

KEGG Gene ID

sce:YJL074C

PubChem

853371

Alliance of Genome Resources

SGD:S000003610

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Chromosome
Coiled coil
Mitosis
Nucleus
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P47037	DA-box protein SMC3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
replication-born double-strand break repair via sister chromatid exchange	IMP	16888651
synaptonemal complex assembly	IMP	10412984
cell division	IEA
chromosome segregation	IEA
meiotic sister chromatid cohesion	IMP	10412984

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

cellular process [inference]

cell cycle process [inference]

chromosome segregation

sister chromatid cohesion [inference]

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

cell cycle G2/M phase transition [inference]

G2/M transition of mitotic cell cycle

meiotic cell cycle process [inference]

reciprocal meiotic recombination

chromosome organization involved in meiotic cell cycle [inference]

synaptonemal complex assembly

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

G2/M transition of mitotic cell cycle

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

cell division

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization

sister chromatid cohesion [inference]

chromosome organization involved in meiotic cell cycle [inference]

synaptonemal complex assembly

synaptonemal complex organization [inference]

synaptonemal complex assembly

cellular component assembly [inference]

synaptonemal complex assembly

reproductive process [inference]

meiotic cell cycle process [inference]

reciprocal meiotic recombination

chromosome organization involved in meiotic cell cycle [inference]

synaptonemal complex assembly

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

double-strand break repair [inference]

double-strand break repair via homologous recombination [inference]

replication-born double-strand break repair via sister chromatid exchange

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mitotic cohesin complex	IBA IDA	9990856
nucleus	IDA IEA	15282802
chromosome	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

cohesin complex [inference]

mitotic cohesin complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
ATP hydrolysis activity	IDA IEA	17055978
double-stranded DNA binding	IBA
protein kinase binding	IPI	27325700
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

double-stranded DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Structural maintenance of

Functional Category

C: Energy production and conversion
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 5** entries
Gene Ontology
ATP binding
cell division
cohesin loader activity
double-stranded DNA binding
mitotic sister chromatid cohesion

Displaying **all 6** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
RecF/RecN/SMC, N-terminal
SMCs flexible hinge superfamily
SMCs flexible hinge
Structural maintenance of chromosomes 3, ABC domain, eukaryotic
Structural maintenance of chromosomes protein

KEGG BRITE Database

Orthology

K06669

Name

structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6)

References

11076961

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
nucleus	PMID:15282802
mitotic cohesin complex	PMID:9990856

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080507	Cornelia de Lange syndrome 3	Alliance of Genome Resources
DOID:1059	intellectual disability	Alliance of Genome Resources
DOID:11725	Cornelia de Lange syndrome	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 30 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	9126		HGNC:2468
Mus musculus	13006		MGI:1339795
Rattus norvegicus	29486		RGD:62006
Drosophila melanogaster	32627		FB:FBgn0015615
Caenorhabditis elegans	176559		WB:WBGene00004873
Danio rerio	324475		ZFIN:ZDB-GENE-030131-3196
Kluyveromyces lactis	2896597	28985_0:000021
Eremothecium gossypii ATCC 10895	4618598	284811_0:00003e
Vanderwaltozyma polyspora DSM 70294	5547829	436907_0:0014b0
Zygosaccharomyces rouxii	8206739	4956_0:00127b

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements