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leucine rich repeat containing G protein-coupled receptor 5

Summary

Gene Symbol

LGR5

Organism

Homo sapiens (human)

External Links

NCBI Gene

8549

PubChem

8549

Alliance of Genome Resources

HGNC:4504

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
G-protein coupled receptor
Glycoprotein
Golgi apparatus
Leucine-rich repeat
Receptor
Reference proteome
Repeat
Signal
Transducer
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0A8K8C7
O75473	G-protein coupled receptor 49 G-protein coupled receptor 67 G-protein coupled receptor HG38

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
hair follicle development	IEA
G protein-coupled receptor signaling pathway	IEA
adenylate cyclase-activating G protein-coupled receptor signaling pathway
oocyte differentiation	IEA
regulation of cell population proliferation	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

cell population proliferation [inference]

epithelial cell proliferation [inference]

epithelial cell proliferation involved in renal tubule morphogenesis

cellular process involved in reproduction in multicellular organism [inference]

oocyte differentiation

cellular developmental process [inference]

cell differentiation [inference]

oocyte differentiation

reproductive process [inference]

developmental process involved in reproduction [inference]

oocyte differentiation

cellular process involved in reproduction in multicellular organism [inference]

oocyte differentiation

multicellular organismal process [inference]

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

developmental process [inference]

developmental process involved in reproduction [inference]

oocyte differentiation

anatomical structure development [inference]

cellular developmental process [inference]

cell differentiation [inference]

oocyte differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

adenylate cyclase-modulating G protein-coupled receptor signaling pathway [inference]

adenylate cyclase-activating G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
trans-Golgi network membrane	IDA	23439653

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

plasma membrane

organelle membrane [inference]

trans-Golgi network membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IDA	21693646 22815884
G protein-coupled receptor activity	IDA	21693646 22815884
protein binding	IPI	21693646 21727895 22815884 23809763 29769720
G protein-coupled peptide receptor activity
protein-hormone receptor activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity [inference]

peptide receptor activity [inference]

G protein-coupled peptide receptor activity

transmembrane signaling receptor activity

G protein-coupled receptor activity

G protein-coupled peptide receptor activity

protein-hormone receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

leucine-rich repeat-containing

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
G protein-coupled peptide receptor activity
hormone-mediated signaling pathway
protein-hormone receptor activity

Displaying **all 6** entries
InterPro
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
Glycoprotein hormone receptor family
Leucine-rich repeat domain superfamily
Leucine-rich repeat, typical subtype
Leucine-rich repeat

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	8549	Xenbase:XB-GENE-994091
Mus musculus	14160	Xenbase:XB-GENE-994091	MOUSE01525
Drosophila melanogaster	55366	FB:FBgn0003255
Drosophila melanogaster	59352	FB:FBgn0003255
Drosophila melanogaster	107515	FB:FBgn0003255
Drosophila melanogaster	286994	FB:FBgn0003255
Rattus norvegicus	299802	Xenbase:XB-GENE-994091	RATNO37558
Drosophila melanogaster	329252	FB:FBgn0003255
Bos taurus	520189		BOVIN28847
Drosophila melanogaster	558825	FB:FBgn0003255