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MAP kinase activating death domain

Summary

Gene Symbol

MADD

Organism

Homo sapiens (human)

External Links

NCBI Gene

8567

PubChem

8567

Alliance of Genome Resources

HGNC:6766

Annotation

Keyword

Alternative splicing
Apoptosis
Cell membrane
Cell projection
Cytoplasm
Guanine-nucleotide releasing factor
Intellectual disability
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0A0MRB5
Q8WXG6	Differentially expressed in normal and neoplastic cells Insulinoma glucagonoma clone 20 Rab3 GDP/GTP exchange factor Rab3 GDP/GTP exchange protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
cell surface receptor signaling pathway	TAS	9115275
regulation of Rab protein signal transduction	IDA	20937701
regulation of Rab protein signal transduction	IBA
regulation of apoptotic process	IMP	11577081
regulation of apoptotic process	IBA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

execution phase of apoptosis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rab protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rab protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rab protein signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of programmed cell death [inference]

regulation of apoptotic process

regulation of apoptotic signaling pathway [inference]

regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway via death domain receptors

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cell cycle

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytoplasm	TAS	8988362
cytosol	TAS
cytosol	IDA
cytosol	IBA
plasma membrane	IDA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	16273344 21044950 9115275
protein kinase activator activity	TAS	9115275

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

cytokine receptor binding [inference]

tumor necrosis factor receptor superfamily binding [inference]

death receptor binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

map kinase-activating death domain protein

Functional Category

G: Carbohydrate transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
regulation of Rab protein signal transduction
regulation of apoptotic process

Displaying **all 6** entries
InterPro
DENN domain, C-terminal lobe
MAP kinase-activating death domain protein
Tripartite DENN domain
cDENN domain
dDENN domain
uDENN domain

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus laevis	8567	Xenbase:XB-GENE-17338004
Danio rerio	32442	ZFIN:ZDB-GENE-030131-8076
Rattus norvegicus	94193		RATNO26495
Mus musculus	228355	ZFIN:ZDB-GENE-030131-8076	MOUSE32559
Pan troglodytes	451167		PANTR02800
Canis lupus familiaris	475982		CANLF05848
Bos taurus	534306		BOVIN07528
Macaca mulatta	713613		MACMU09512
Monodelphis domestica	100012321		MONDO26799
Ornithorhynchus anatinus	100082325		ORNAN19090